Ultra-LEAF™ Purified anti-human/mouse TGF-&b
- 产品名称：
- Ultra-LEAF™ Purified anti-human/mouse TGF-&b
- 产品类别：
- 抗体
- 产品编号：
- 947303
- 产品应用：
- 947303
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- Human TGF-β1
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralizing the inhibition of HT-2 cell proliferation induced by recombinant human TGF-β1 (0.4 ng/mL, Cat. No. 781802). ND50 range: 0.05 – 0.25 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2910510 (BioLegend Cat. No. 947303) AB_2910510 (BioLegend Cat. No. 947304)
- Structure
- Homodimer
- Distribution
-
TGF-β1 is secreted by numerous cells
- Function
- Regulation of cell growth and survival, cell and tissue differentiation, development, inflammation, immunity, hematopoiesis, and tissue remodeling and repair. Essential for wound healing, stimulates matrix molecule deposition and angiogenesis, and is an essential mediator of the pathologic scarring in fibrotic disorders
- Interaction
- Embryonic stem cells, endothelial cells, fibroblasts, mesenchymal cells, mesenchymal stem cells, neural stem cells, osteoclasts, Th17, Tregs
- Ligand/Receptor
- TGF-β1 binds to type II and type I serine/threonine kinase receptors, which initiate intracellular signals through activation of Smad proteins.
- Cell Type
- Tregs
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
-
- Sun X, et al. 2013. J Virol. 87:10126-38.
- Benlhabib H, et al. 2015. J Biol Chem. 290:22409-22.
- Lin C, et al. 2016. J Exp Med. 213:251-71.
- Chen P, et al. 2016. Sci Rep. 6:33407.
- de la Mare J, et al. 2017. BMC Cancer. 17:202.
- Du C, et al. 2017. Int J Biochem Cell Biol. 90:17-28.
- Nüchel J, et al. 2018. Autophagy. 14:465-486.
- Gene ID
- 7040 View all products for this Gene ID
- UniProt
- View information about TGF-beta1 on UniProt.org
