Anti-BACE1 (CO2 terminus) Antibody (Previously Cov-上海雅吉生物科技有限公司

规格	价格	库存
100µL	￥ 5866	1

Product Details

Verified Reactivity

Human, Mouse, Rat

Antibody Type

Polyclonal

Host Species

Rabbit

Immunogen

B690 was raised against a peptide sequence CLRQQHDDFADDISLLK , the C-terminal 17 amino acids of the human BACE1 and recognizes the mature and immature forms of BACE.

Preparation

Serum

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C.

Application

WB, ICC, IP

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting.

The optimal working dilution should be determined for each specific assay condition.
? WB: 1:1,000
? ICC: 1:300
? IP: 1:200

Application Notes

This antibody is effective in immunoblotting, immunocytochemistry, (ICC) and immunoprecipitation (IP).

Processing of the β-amyloid precursor protein (βAPP) by two endopeptidases, β and γ secretases generates the amyloidogenic peptide Aβ, a major factor in the etiology of Alzheimers disease. The beta secretase is a novel membrane bound aspartyl protease which cleaves the β-APP to generate the N-terminus of the Aβ domain. The membrane bound C-terminal fragment generated by the beta secretase cut is subsequently cleaved by the gamma secretase, resulting in the generation and secretion of Aβ.

Clone also known as B690.

This product may contain other non-IgG subtypes.

Application References (PubMed link indicates BioLegend citation)

Yan R, Han P, Miao H, Greengard P, Xu H. The transmembrane domain of the Alzheimer's beta-secretase (BACEdetermines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate. J Biol Chem 276(39):36788-36796, 2001. (WB, IP)
Lysenko LV, et al. 2014. PLoS One.9:114521. (WB) PubMed

Product Citations