Purified anti-sAPPβ Antibody (Previously Cova
- 产品名称：
- Purified anti-sAPPβ Antibody (Previously Cova
- 产品类别：
- 抗体
- 产品编号：
- 813401
- 产品应用：
- 813401
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Polyclonal
- Host Species
- Rabbit
- Formulation
- Phosphate-buffered solution (no preservatives or carrier proteins).
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1.0 mg/ml
- Storage & Handling
- Do not store antibody diluted below 50 ?g/mL in the absence of protein (i.e. add 2% bovine serum albumin). The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 - 2 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is specific for the soluble fragment cleaved n-terminus to the beta secretase cleavage site of amyloid precursor protein. It has neglible cross reactivity to sAPPa or full length APP.
This product may contain other non-IgG subtypes.
- Application References
(PubMed link indicates BioLegend citation) -
- Freude, Kristine K., et al. Soluble Amyloid Precursor Protein Induces Rapid Neural Differentiation of Human Embryonic Stem Cells. J. Biol. Chem.:286(27): 24264 - 24274, Jul 2011. (WB) PubMed
- Ellen Jorissen, et al. The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex. J. Neurosci.: 30(14): 4833 - 4844, Apr 2010. (WB) PubMed
- Qiu-Lan Ma, MD, PhD, et al. Reduction of SorLA/LR11, a Sorting Protein Limiting beta-Amyloid Production, in Alzheimer Disease Cerebrospinal Fluid. Arch Neurol:66(4): 448-457, Apr 2009. (WB) PubMed
- Corbett GT, et al. 2015. PNAS. PubMed
- Product Citations
-
- Qin X, Wang Y, Paudel H 2016. J Biol Chem. 291: 22276 - 22287. PubMed
- Zhong BR, et al. 2021. The FASEB Journal. 35(5):e21445. PubMed
- Jorissen E, et al. 2010. J Neurosci. 30:4833-4844. PubMed
- Zheng Q, et al. 2022. J Clin Invest. 132:. PubMed
- Li KY, et al. 2020. Journal of Neurochemistry. 157(4):1351-1365. PubMed
- Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
- Freude K, et al. 2011. J Biol Chem. 286:24264-24274. PubMed
- Tambini MD, et al. 2020. Elife. 9:e52612. PubMed
- Rabinovich-Toidman P, et al. 2015. PLoS One. 10: 0143420. PubMed
- Wu Z, et al. 2020. Br J Pharmacol. 1967:177. PubMed
- Xiang J, et al. 2019. Mol Ther Nucleic Acids. 16:302. PubMed
- Jean-Louis T, et al. 2018. Neurobiol Aging. 62:130. PubMed
- Corbett G, et al. 2015. Proc Natl Acad Sci U S A. 112: 8445 - 8450. PubMed
- Salta E, et al. 2016. EMBO Mol Med. 8: 1005 - 1018. PubMed
- Ma Q, et al. 2009. Arch Neurol. 66:448-457. PubMed
- Wang W et al. 2019. EBioMedicine. 42:174-187 . PubMed
- Marwarha G, et al. 2018. J Neurochem. 144:761. PubMed
- RRID
- AB_2564769 (BioLegend Cat. No. 813401)
