Biotin anti-rat IL-6 Antibody
- 产品名称：
- Biotin anti-rat IL-6 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 517703
- 产品应用：
- 517703
- Verified Reactivity
- Rat
- Antibody Type
- Polyclonal
- Host Species
- Goat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
ELISA Detection - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. For sandwich ELISA detection applications, a concentration range of 0.1-0.2 μg/ml is recommended when used in conjunction with the purified Poly5177 antibody (Cat. No. 517701) as the detecting antibody. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Poly5177 is 4.1% cross-reactive with mouse IL-6 as measured by ELISA.
- Product Citations
-
- Allen KD, et al. 2020. Connect Tissue Res. 61:82. PubMed
- RRID
- AB_2561416 (BioLegend Cat. No. 517703)
- Structure
- 187 amino acids (aa) in length, and 39% and 87% aa sequence identity with human and mouse IL-6, respectively.
- Distribution
- Secreted by a variety of lymphoid and non-lymphoid cells including T cells, B cells, monocytes, fibroblasts, hepatocytes, endothelial cells, keratinocytes and muscle cells, etc.
- Function
- A pleiotropic cytokine that plays important roles in innate and adaptive immunity. Also important for hematopoiesis, bone metabolism, and cancer progression.
- Ligand/Receptor
- IL-6 receptor
- Cell Type
- B cells, Dendritic cells
- Biology Area
- Angiogenesis, Cell Biology, Immunology, Innate Immunity
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Heinrich PC, et al. 1990. Biochem. J. 265:621.
2. Hibi M, et al. 1996. J. Mol. Med. 74:1.
3. Hirano T, et al. 1994. Stem Cells 12:262.
4. Taga T and Kishimoto T. et al. 1997. Annu. Rev. Immunol. 15:797.
5. Van Snick J. 1990. Annu. Rev. Immunol. 8:253.
- Regulation
- Expression can be induced by numerous signals such as mitogenic or antigenic stimulation, lipopolysaccharides, calcium ionophores, cytokines, and viruses.
- Gene ID
- 24498 View all products for this Gene ID
- UniProt
- View information about IL-6 on UniProt.org
