Purified anti-Presenilin 1 (NH2-terminus) Antibod
- 产品名称：
- Purified anti-Presenilin 1 (NH2-terminus) Antibod
- 产品类别：
- 抗体
- 产品编号：
- 811101
- 产品应用：
- 811101
- Verified Reactivity
- Human
- Antibody Type
- Polyclonal
- Host Species
- Rabbit
- Immunogen
- This polyclonal antibody was raised against a peptide corresponding to the N-terminus of human PS1.
- Molecular Mass
- Expected MW 50kD and 30kD
- Formulation
- Phosphate-buffered solution + 0.03% Thimerosal.
- Preparation
- The antibody was purified by antigen affinity.
- Concentration
- 1.0 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
- Application
-
WB, ICC, IP
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting.
The optimal working dilution should be determined for each specific assay condition.
? Western blot: 1:1,000*
- Application Notes
This antibody is effective in immunoblotting (WB).
WB Positive Control: Human Brain lysate
This product may contain other non-IgG subtypes.
- Application References
(PubMed link indicates BioLegend citation) -
- Gu Y, Sanjo N, Chen F, Hasegawa H, Petit A, Ruan X, Li W, Shier C, Kawarai T, Schmitt-Ulms G, Westaway D, St George-Hyslop P, Fraser PE. The presenilin proteins are components of multiple membrane-bound complexes which have different biological activities. J Biol Chem 279(30):31329-31336, 2004.
- Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, George-Hyslop PS. Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin1 and presenilin 2 complexes. J Biol Chem 275(35):27348-27353, 2000.
- Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P, Fraser PE. Carboxyl-terminal fragments of alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells. J Biol Chem 275(47):36794-36802, 2000.
- Product Citations
-
- Lu J, et al. 2016. PLoS One. 11:e0166415. PubMed
- Tambini MD, et al. 2020. J Biol Chem. 295:7442. PubMed
- RRID
- AB_2564752 (BioLegend Cat. No. 811101)
