Alexa Fluor® 594 anti-mouse Podoplanin Antibod
- 产品名称：
- Alexa Fluor® 594 anti-mouse Podoplanin Antibod
- 产品类别：
- 抗体
- 产品编号：
- 156205
- 产品应用：
- 156205
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Peptide (38-51 amino acids of mouse podoplanin)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 594 under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
IHC-F - Quality tested
3D IHC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 5.0 - 10 ?g/mL is suggested.?For 3D immunohistochemistry on formalin-fixed tissues, a concentration of 5.0 ?g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor? 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Application References
(PubMed link indicates BioLegend citation) -
- Yamada S, et al. 2017. Monoclon Antib Immunodiagn Immunother. 36(2):77-79.
- RRID
- AB_2800698 (BioLegend Cat. No. 156205) AB_2819915 (BioLegend Cat. No. 156206)
- Structure
- 43 kD glycosylated type-1 transmembrane protein. Mucin-type protein.
- Distribution
-
Expressed on epithelial and mesothelial cells.
- Function
- Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation.
- Interaction
- Interacts with CLEC1B; the interaction is independent of CLEC1B glycosylation and activates CLEC1B; the interaction is dependent of sialic acid on O-glycans.
- Ligand/Receptor
- CLEC1B
- Cell Type
- Epithelial cells
- Biology Area
- Cancer Biomarkers, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
- Antigen References
-
- Farr A, et al. 1992. J Histochem Cytochem. 40:651.
- Schacht V, et al. 2005. Am J Pathol. 166:913.
- Gene ID
- 14726 View all products for this Gene ID
- UniProt
- View information about Podoplanin on UniProt.org
