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首页 > 抗体蛋白 > 抗体
Purified anti-mouse NK-1.1 Antibody
产品名称：
Purified anti-mouse NK-1.1 Antibody
产品类别：
抗体
产品编号：
108701
产品应用：
108701
[价格]
规格 价格 库存
50µg ￥ 420 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
NK-1+ cells from mouse spleen and bone marrow
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF? - Verified
IP, Deplete, Block, IHC-F - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1,2, complement-dependent cytotoxicity3, in vivo depletion4,5,9,10, mediation of in vitro redirected lysis6, blocking of NK cell function7, induction of proliferation8, immunohistochemical staining of frozen sections11, immunofluorescence microscopy11, and spatial biology (IBEX)16,17. The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 108712).

Application References

(PubMed link indicates BioLegend citation)
  1. Carlyle JR, et al. 1999. J. Immunol. 162:5917. (IP)
  2. Sentman CL, et al. 1989. Hybridoma 8:605. (IP)
  3. Koo GC, et al. 1984. Hybridoma 3:301. (Cyt)
  4. Sentman CL, et al. 1989. J. Immunol. 142:1847. (Deplete)
  5. Koo GC, et al. 1986. J. Immunol. 137:3742. (Deplete)
  6. Karlhofer FM, et al. 1991. J. Immunol. 146:3662.
  7. Kung SK, et al. 1999. J. Immunol. 162:5876. (Block)
  8. Reichlin A, et al. 1998. Immunol. Cell Biol. 76:143.
  9. Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  10. Andoniou CE, et al. 2005. Nat. Immunol. 6:1011. (Deplete)
  11. Kanwar JR, et al. 2001. J. Natl. Cancer Inst. 93:1541. (IHC, IF)
  12. Kroemer A, et al. 2008. J. Immunol. 180:7818. PubMed
  13. Kim JY, et al. 2009. Exp Mol Med. 30:288. PubMed
  14. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  15. Lee H, et al. 2014. Invest Ophthalmol Vis Sci. 55:2885. PubMed
  16. Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
  17. Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
Product Citations
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  8. Goel S, et al. 2017. Nature. 548:471. PubMed
  9. Lee H, et al. 2014. Invest Ophthalmol Vis Sci . 55:2885. PubMed
  10. Hu D, et al. 2021. J Cell Mol Med. 25:2900. PubMed
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  13. Lee JH, et al. 2022. iScience. 25:104166. PubMed
  14. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  15. Peng V, et al. 2020. J Biol Chem. 295:14866. PubMed
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  17. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  18. O'Dea KP, et al. 2020. J Extracell Vesicles. 9:1706708. PubMed
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  20. Seelige R, et al. 2018. Sci Rep. 8:13670. PubMed
  21. Yang SH, et al. 2017. Front Immunol. 8:1192. PubMed
  22. Hiratsuka S, et al. 2018. EMBO Mol Med. 10:e8643. PubMed
  23. Hosomi S, et al. 2017. J Exp Med. 214:2985. PubMed
  24. Stacey MA, et al. 2017. J Clin Invest. 127:1463. PubMed
  25. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  26. Cong J et al. 2018. Cell metabolism. 28(2):243-255 . PubMed
  27. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  28. Sodji QH, et al. 2022. Cancer Res Commun. 2:725. PubMed
  29. Ma W, et al. 2017. Sci Rep. . 10.1038/s41598-017-15661-6. PubMed
  30. Xie D, et al. 2020. Eur J Immunol. 50:1729. PubMed
  31. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  32. Zhong X, et al. 2020. Proc Natl Acad Sci U S A. 8563:117. PubMed
  33. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  34. Hoves S, et al. 2018. J Exp Med. 215:859. PubMed
  35. Simonović N, et al. 2019. J Immunol. 202:1724. PubMed
  36. Du J, et al. 2018. AMB Express. 8:158. PubMed
  37. Shin J, et al. 2018. Diabetes. 67:1068. PubMed
  38. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  39. Jang SC, et al. 2021. Commun Biol. 4:497. PubMed
  40. You X, et al. 2022. Front Genet. 12:790990. PubMed
  41. Renand A, et al. 2018. J Allergy Clin Immunol. 141:1750. PubMed
  42. Sanmarco LM, et al. 2021. Nature. 590:473. PubMed
  43. Chen HW, et al. 2021. Biomedicines. 9:. PubMed
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  45. Yoon BH, et al. 2018. Mol Cells. 41:953. PubMed
  46. Pasciuto E, et al. 2020. Cell. 182:625. PubMed
  47. Nair S, et al. 2021. JCI Insight. 6:. PubMed
  48. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
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  50. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  51. Akiel M, et al. 2017. Cancer Res. 77:4014. PubMed
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  53. Aguilar OA, et al. 2020. J Immunol. 205:1709. PubMed
  54. Liu Q, et al. 2022. Front Immunol. 13:875718. PubMed
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RRID
AB_313388 (BioLegend Cat. No. 108701) AB_313389 (BioLegend Cat. No. 108702)

Antigen Details

Structure
NKR-P1 gene family
Distribution

NK and NK-T cells in the NK1.1 mouse strains (C57BL, FVB/N, NZB)

Function
NK cell activation, IFN-γ production, cytotoxic granule release
Cell Type
NK cells, NKT cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Lanier LL. 1997. Immunity 6:371.
2. Yokoyama WM, et al. 1993. Ann. Rev. Immunol. 11:613.
3. Koo GC, et al. 1986. J. Immunol. 137:3742.
4. Giorda R, et al. 1991. J. Immunol. 147:1701.

Gene ID
17059 View all products for this Gene ID
UniProt
View information about NK-1.1 on UniProt.org

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