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首页 > 抗体蛋白 > 抗体
PE/Cyanine7 anti-mouse NK-1.1 Antibody
产品名称：
PE/Cyanine7 anti-mouse NK-1.1 Antibody
产品类别：
抗体
产品编号：
108713
产品应用：
108713
[价格]
规格 价格 库存
25µg ￥ 1218 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
NK-1+ cells from mouse spleen and bone marrow
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1,2, complement-dependent cytotoxicity3, in vivo depletion4,5,9,10, mediation of in vitro redirected lysis6, blocking of NK cell function7, induction of proliferation8, immunohistochemical staining of frozen sections11, immunofluorescence microscopy11, and spatial biology (IBEX)16,17. The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 108712).

Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References

(PubMed link indicates BioLegend citation)
  1. Carlyle JR, et al. 1999. J. Immunol. 162:5917. (IP)
  2. Sentman CL, et al. 1989. Hybridoma 8:605. (IP)
  3. Koo GC, et al. 1984. Hybridoma 3:301. (Cyt)
  4. Sentman CL, et al. 1989. J. Immunol. 142:1847. (Deplete)
  5. Koo GC, et al. 1986. J. Immunol. 137:3742. (Deplete)
  6. Karlhofer FM, et al. 1991. J. Immunol. 146:3662.
  7. Kung SK, et al. 1999. J. Immunol. 162:5876. (Block)
  8. Reichlin A, et al. 1998. Immunol. Cell Biol. 76:143.
  9. Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  10. Andoniou CE, et al. 2005. Nat. Immunol. 6:1011. (Deplete)
  11. Kanwar JR, et al. 2001. J. Natl. Cancer Inst. 93:1541. (IHC, IF)
  12. Kroemer A, et al. 2008. J. Immunol. 180:7818. PubMed
  13. Kim JY, et al. 2009. Exp Mol Med. 30:288. PubMed
  14. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  15. Lee H, et al. 2014. Invest Ophthalmol Vis Sci. 55:2885. PubMed
  16. Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
  17. Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
Product Citations
  1. Madireddi S, et al. 2014. J Exp Med. 211:1433. PubMed
  2. Harsha Krovi S, et al. 2020. Nat Commun. 4.790277778. PubMed
  3. Tran NT, et al. 2019. Cell Rep. 28:3510. PubMed
  4. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  5. McNamara HA, et al. 2020. Cell Host Microbe. 572:28. PubMed
  6. Wu N, et al. 2020. Cell Rep. 30:1129. PubMed
  7. Zhou J, et al. 2019. Immunity. 50:403. PubMed
  8. Du H et al. 2019. Cancer cell. 35(2):221-237 . PubMed
  9. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  10. Fu B et al. 2017. Immunity. 47(6):1100-1113 . PubMed
  11. Liu QZ, et al. 2018. Front Immunol. 1.131944444. PubMed
  12. Piepke M, et al. 2021. J Neuroinflammation. 18:265. PubMed
  13. Earnest JT, et al. 2021. Cell Reports. 35(1):108962. PubMed
  14. Clement M, et al. 2016. PLoS Pathog. 12:e1006050. PubMed
  15. Chow MT et al. 2019. Immunity. 50(6):1498-1512 . PubMed
  16. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  17. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  18. Campana L, et al. 2018. J Immunol. 200:1169. PubMed
  19. Yang X, et al. 2019. Oncotarget. 10:4180. PubMed
  20. Dai B, et al. 2022. Theranostics. 12:7603. PubMed
  21. Robbins G, et al. 2012. J Biol Chem. 287:24294. PubMed
  22. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  23. Qu J, et al. 2018. J Immunol Res. 2018:7519856. PubMed
  24. Cong M, et al. 2021. Methods Mol Biol. 2388:59. PubMed
  25. Chun E, et al. 2020. Immunity. 51(5):871-884.e6.. PubMed
  26. Cong J et al. 2018. Cell metabolism. 28(2):243-255 . PubMed
  27. Hutter K, et al. 2020. FEBS J. . PubMed
  28. Ma W, et al. 2017. Sci Rep. . 10.1038/s41598-017-15661-6. PubMed
  29. McFarland AP, et al. 2021. Immunity. 54(6):1320-1337.e4. PubMed
  30. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  31. Liu W, et al. 2019. Epigenetics. 1.192361111. PubMed
  32. Wu B, et al. 2020. Int J Biol Sci. 16:1526. PubMed
  33. Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed
  34. Fu Z, et al. 2021. Cell Res. 31:631. PubMed
  35. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  36. Ma W, et al. 2017. Cell Death & Disease. 10.1038/cddis.2017.47. PubMed
  37. Huang J, et al. 2014. J Immunol. 192:1972. PubMed
  38. Zhang X, et al. 2021. Mol Cancer Res. 19:1076. PubMed
  39. Itoga M, et al. 2015. PLoS One. 10: e0123210. PubMed
  40. Bitschar K, et al. 2019. Nat Commun. 10:2730. PubMed
  41. Zeis P, et al. 2020. Immunity. 53:775. PubMed
  42. Shissler SC, et al. 2020. Sci Rep. 10:8218. PubMed
  43. Zhao X, et al. 2022. iScience. 25:104690. PubMed
  44. Porrello A, et al. 2018. Nat Commun. 9:1988. PubMed
  45. Shimba A et al. 2018. Immunity. 48(2):286-298 . PubMed
  46. Hayashida E, et al. 2019. J Neuroinflammation. 0.789583333. PubMed
  47. Han P, et al. 2020. Sci Adv. 6:eaaz1580. PubMed
  48. Hsia HC, et al. 2017. J Leukoc Biol. 101:1053. PubMed
  49. Verma M, et al. 2021. J Exp Med. 218:. PubMed
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  51. Leruste A, et al. 2020. Cancer Cell. 36(6):597-612.e8.. PubMed
RRID
AB_389363 (BioLegend Cat. No. 108713) AB_389364 (BioLegend Cat. No. 108714)

Antigen Details

Structure
NKR-P1 gene family
Distribution

NK and NK-T cells in the NK1.1 mouse strains (C57BL, FVB/N, NZB)

Function
NK cell activation, IFN-γ production, cytotoxic granule release
Cell Type
NK cells, NKT cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Lanier LL. 1997. Immunity 6:371.
2. Yokoyama WM, et al. 1993. Ann. Rev. Immunol. 11:613.
3. Koo GC, et al. 1986. J. Immunol. 137:3742.
4. Giorda R, et al. 1991. J. Immunol. 147:1701.

Gene ID
17059 View all products for this Gene ID
UniProt
View information about NK-1.1 on UniProt.org

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