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APC/Cyanine7 anti-mouse NK-1.1 Antibody
产品名称：
APC/Cyanine7 anti-mouse NK-1.1 Antibody
产品类别：
抗体
产品编号：
108723
产品应用：
108723
[价格]
规格 价格 库存
25µg ￥ 1316 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
NK-1+ cells from mouse spleen and bone marrow
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1,2, complement-dependent cytotoxicity3, in vivo depletion4,5,9,10, mediation of in vitro redirected lysis6, blocking of NK cell function7, induction of proliferation8, immunohistochemical staining of frozen sections11, immunofluorescence microscopy11, and spatial biology (IBEX)16,17. The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 108712).

Additional Product Notes
BioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References

(PubMed link indicates BioLegend citation)
  1. Carlyle JR, et al. 1999. J. Immunol. 162:5917. (IP)
  2. Sentman CL, et al. 1989. Hybridoma 8:605. (IP)
  3. Koo GC, et al. 1984. Hybridoma 3:301. (Cyt)
  4. Sentman CL, et al. 1989. J. Immunol. 142:1847. (Deplete)
  5. Koo GC, et al. 1986. J. Immunol. 137:3742. (Deplete)
  6. Karlhofer FM, et al. 1991. J. Immunol. 146:3662.
  7. Kung SK, et al. 1999. J. Immunol. 162:5876. (Block)
  8. Reichlin A, et al. 1998. Immunol. Cell Biol. 76:143.
  9. Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  10. Andoniou CE, et al. 2005. Nat. Immunol. 6:1011. (Deplete)
  11. Kanwar JR, et al. 2001. J. Natl. Cancer Inst. 93:1541. (IHC, IF)
  12. Kroemer A, et al. 2008. J. Immunol. 180:7818. PubMed
  13. Kim JY, et al. 2009. Exp Mol Med. 30:288. PubMed
  14. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  15. Lee H, et al. 2014. Invest Ophthalmol Vis Sci. 55:2885. PubMed
  16. Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
  17. Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
Product Citations
  1. Chung Y, et al. 2014. J Vis Exp. 89: 51660. PubMed
  2. Djokić V, et al. 2019. Front Immunol. 9:2891. PubMed
  3. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  4. Zhou J, et al. 2019. Immunity. 50:403. PubMed
  5. Xu W et al. 2019. Immunity. 50(4):1054-1068 . PubMed
  6. Hirata Y et al. 2018. Cell stem cell. 22(3):445-453 . PubMed
  7. Qiao Y, et al. 2021. Oncoimmunology. 10:1947569. PubMed
  8. Coleby R, et al. 2021. Clin Exp Rheumatol. :39. PubMed
  9. Mitchell A, et al. 2012. J Immunol. 189:4970. PubMed
  10. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  11. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  12. Dos Santos Dias L, et al. 2021. PLoS Pathog. e1009324:17. PubMed
  13. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  14. Aldrich AL, et al. 2021. The Journal of Immunology. 206(4):751-765. PubMed
  15. Bunn P, et al. 2014. J Immunol. 192:3709. PubMed
  16. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  17. Derecka M, et al. 2020. Nat Immunol. 261:21. PubMed
  18. Li J, et al. 2018. Immunity. 49:178. PubMed
  19. Brodin P, et al. 2010. PLoS One. 5:e13174. PubMed
  20. Grune J, et al. 2022. Nat Cardiovasc Res. 1:649. PubMed
  21. Mulas F, et al. 2020. Cell Mol Immunol. . PubMed
  22. Ringel AE, et al. 2020. Cell. 183(7):1848-1866.e26. PubMed
  23. Goossens P, et al. 2019. Cell Metab. 29:1376. PubMed
  24. Panea C, et al. 2021. Commun Biol. 4:913. PubMed
  25. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  26. Rohner L, et al. 2020. Sci Rep. 0.570833333. PubMed
  27. Kr?utler NJ, et al. 2020. Cell Reports. 30(4):997-1012.e6.. PubMed
  28. De Veirman K, et al. 2021. Oncoimmunology. 10:2000699. PubMed
  29. Lee L, et al. 2016. PLoS One. 11:e0167693. PubMed
  30. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  31. DiToro D, et al. 2020. Immunity. 650:52. PubMed
  32. Etzerodt A, et al. 2019. J Exp Med. 216:2394. PubMed
  33. Desai P, et al. 2021. Cell. 184(5):1214-1231.e16. PubMed
  34. Barth ND, et al. 2018. J Immunol. 201:2602. PubMed
  35. Kiyohara H, et al. 2018. Cell Mol Gastroenterol Hepatol. 7:135. PubMed
  36. Lee SC et al. 2018. Cancer cell. 34(2):225-241 . PubMed
  37. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  38. Akoolo L, et al. 2021. Cell Microbiol. 23:e13350. PubMed
  39. Montes de Oca M, et al. 2016. PLoS Pathog. 12: 1005398. PubMed
  40. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  41. Katzmarski N, et al. 2021. Nat Immunol. 22:1382. PubMed
  42. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  43. Ramanan D, et al. 2020. Cell. 181(6):1276-1290. PubMed
  44. Seo GY et al. 2018. Cell host & microbe. 24(2):249-260 . PubMed
  45. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  46. Rodrigues KA, et al. 2021. Sci Adv. 7:eabj6538. PubMed
  47. Etzerodt A, et al. 2020. J Exp Med. 217:00:00. PubMed
  48. Lee S, et al. 2021. Autophagy. Online ahead of print. PubMed
  49. Amend A, et al. 2021. Int J Mol Sci. 22:. PubMed
RRID
AB_830870 (BioLegend Cat. No. 108723) AB_830871 (BioLegend Cat. No. 108724)

Antigen Details

Structure
NKR-P1 gene family
Distribution

NK and NK-T cells in the NK1.1 mouse strains (C57BL, FVB/N, NZB)

Function
NK cell activation, IFN-γ production, cytotoxic granule release
Cell Type
NK cells, NKT cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Lanier LL. 1997. Immunity 6:371.
2. Yokoyama WM, et al. 1993. Ann. Rev. Immunol. 11:613.
3. Koo GC, et al. 1986. J. Immunol. 137:3742.
4. Giorda R, et al. 1991. J. Immunol. 147:1701.

Gene ID
17059 View all products for this Gene ID
UniProt
View information about NK-1.1 on UniProt.org

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