Purified anti-Tau Phospho (Thr231) Antibody (Previ
- 产品名称：
- Purified anti-Tau Phospho (Thr231) Antibody (Previ
- 产品类别：
- 抗体
- 产品编号：
- 828903
- 产品应用：
- 828903
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- The PHF-6 antibody was raised using PHF-tau preparations from human brain.
- Formulation
- Phosphate-buffered solution; no preservatives or carrier proteins.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1.0 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
- Application
-
WB
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting.
The optimal working dilution should be determined for each specific assay condition.
? WB: 1:1,000
- Application Notes
This antibody is effective in immunoblotting (WB).
The PHF-6 antibody reacts with human tau phosphorylated at Thr 231.
- Application References
(PubMed link indicates BioLegend citation) -
- Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Sarmiento J, Troncoso J, Jackson GR, and Kayed R. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J, 26: 1946-1959, May 2012.
- Mitchell TW, Nissanov J, Han LY, Mufson EJ, Schneider JA, Cochran EJ, Bennett DA, Lee VM, Trojanowski JQ, Arnold SE. Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment. J Histochem Cytochem 48(12):1627-1637, 2000.
- Hong M, Chen D, Klein P, Lee V. Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J Biol Chem 272(40):25326-25332, 1997.
- Bramblett GT, Goedert M, Jakes R, Merrick SE, Trojanowski JQ, Lee VM. Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10(6):1089-1099, 1993.
- Product Citations
-
- Loeffler D, et al. 2015. Exp Gerontol. 67: 15-18. PubMed
- RRID
- AB_2715849 (BioLegend Cat. No. 828903) AB_2564924 (BioLegend Cat. No. 828901)
