Purified anti-FOXA2 Antibody
- 产品名称：
- Purified anti-FOXA2 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 685802
- 产品应用：
- 685802
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified recombinant fragment of human FOXA2 expressed in E. Coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g/ml.?For immunocytochemistry, a concentration range of 4.0 - 10 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- Chen YF, et al. 2020. Sci Adv. 6:eaay0264. PubMed
- Truong DJ, et al. 2021. Nat Cell Biol. 23:652. PubMed
- RRID
- AB_2616799 (BioLegend Cat. No. 685802)
- Structure
- 457 amino acids with a predicted molecular weight of approximately 48 kD. An isoform was identified with the predicted molecular weight of approximately 49 kD.
- Distribution
-
Nucleus (but not nucleoli).
- Function
- Interact with the cis-acting regulatory regions of several liver-specific genes. FOXA2 is important for notochord development in embryo. It is also involved in regulation of fat metabolism, glucose homeostasis, TH2-mediated pulmonary inflammation and goblet cell hyperplasia.
- Interaction
- DNA and chromatin.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Transcription Factors
- Antigen References
-
1. Arenas E. 2008. Cell Stem Cell. 2:110.
2. Sun L, et al. 2015. World J. Methodol. 5:223.
3. Li CM, et al. 2015. Genes Dev. 29:1850.
4. Sund NJ, et al. 2001. Genes Dev. 15:1706.
5. Levinson-Dushnik M, Benvenisty N. 1997. Mol. Cell Biol. 17:3817.
- Gene ID
- 3170 View all products for this Gene ID
- UniProt
- View information about FOXA2 on UniProt.org
