Purified anti-Daxx Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 3542	1

规格

价格

库存

100µg

￥ 3542

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant fragment of human Daxx (aa 541-720) expressed in E. coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
ICC - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g/ml. For immunocytochemistry, a concentration range of 5.0 - 10 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: The predicted molecular weight of Daxx is 83 kD. The observed molecular weight is around 110 kD on Western blot due to post-translational hyperphosphorylation. Clone P87A11 does not cross-react with mouse (in-house tested).
RRID: AB_2632649 (BioLegend Cat. No. 691402)

Structure: 740 amino acids with a predicted molecular weight of 83 kD. Contains a SUMO interaction motif at C-terminal region.
Distribution: Mainly located in the nucleus. Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress.
Function: Enhance Fas-mediated apoptosis. Involve in regulation of gene transcription.
Interaction: Daxx is found to have interactions with several different proteins, such as Pax3, CENP-C, DNA methyltransferase I, MCSR1, Fas, STAT3 and promyelocytic leukemia protein (PML).
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Transcription Factors
Antigen References: 1. Yang X, et al. 1997. Cell. 89:1067-76.
2. Schreiner S, Wodrich H. 2013. J. Virol. 87:10412-22.
3. Li H, et al. 2000. Mol. Cell. Biol. 20:1784-96.
4. Takahashi Y, et al. 2004. Oncogene. 23:2819.
Gene ID: 1616 View all products for this Gene ID
UniProt: View information about Daxx on UniProt.org