Purified anti-SMN (Gemin 1) Antibody
- 产品名称：
- Purified anti-SMN (Gemin 1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 867501
- 产品应用：
- 867501
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified recombinant fragment of human SMN1 (amino acids 148-294) expressed in E. Coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 10 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2810803 (BioLegend Cat. No. 867501) AB_2810804 (BioLegend Cat. No. 867502)
- Structure
- SMN1 is a 294 amino acid protein with a predicted molecular mass of ~ 32 kD and an observed molecular mass at ~ 35 kD.
- Distribution
-
Tissue Distribution: Brain, pancreas, gallbladder, bladder, testis, lymph node, and bone marrow
Cellular Distribution: Nucleus and cytosol
- Function
- SMN1 is a component of the SMN complex essential for the formation of snRNP complexes in Eukaryotic cells.
- Interaction
- SMN1 forms homodimer or found in complex with other SMN/GEMIN proteins.
- Cell Type
- Neurons
- Biology Area
- Chromatin Remodeling/Epigenetics, Neurodegeneration, Neuroscience, Synaptic Biology, Transcription Factors
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
- Maretina MA, et al. 2018. Curr. Genomics. 19(5):339-55.
- Singh RN, Singh NN. 2018. Adv. Neurobiol. 20:31-61.
- Groen EJN, et al. 2018. Nat. Rev. Neurol. 14:214-24.
- Gene ID
- 6606 View all products for this Gene ID 6607 View all products for this Gene ID
- UniProt
- View information about SMN on UniProt.org
