Alexa Fluor® 594 anti-eIF4E Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1904	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant full length of human eIF4E (AA: 1-217) expressed in E. coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 594 under optimal conditions.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: ICC -?Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 0.2 - 1.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor? 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.

Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

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Application Notes: Clone P85D11B4 does not cross-react with mouse (in-house tested).
RRID: AB_2650791 (BioLegend Cat. No. 693003)

Structure: 217 amino acids long, and the predicted molecular weight is 25 kD.
Distribution: Cytoplasm
Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Interaction: eIF4E is a multi-subunit complex. It is composed of EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners, eg.EIF4ENIF1, EIF4A1, EIF4A2, NGDN, PIWIL2, CYFIP, FMR1, CLOCK, Lassa virus Z protein, MKNK2, LIMD1, WTIP, AJUBA, APOB
Antigen References: 1. Kapp LD, Lorsch JR. 2004.?Annu. Rev. Biochem.?73: 657.
2. von der Haar T,?et al.?2004.?Nat. Struct. Mol. Biol.?11: 503.
3. Gingras AC,?et al.?1999.?Annu. Rev. Biochem.?68: 913.
4. De Benedetti A, Graff JR. 2004.?Oncogene?23: 3189.
5. Zimmer SG,?et al.?2000.?Anticancer Res.?20:1343.
6. Jia Y,?et al.?2012.?Med. Res. Rev.?32: 786.
7. Graff JR,?et al. 2007.?J. Clin. Invest.?117: 2638.
Gene ID: 1977 View all products for this Gene ID
UniProt: View information about eIF4E on UniProt.org