Purified anti-CDK5 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 4354	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant fragment (aa 120-292) of human CDK5 expressed in E.coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2572168 (BioLegend Cat. No. 684502)

Antigen Details

Structure: 292 amino acids with a predicted molecular weight of approximately 33kD.
Distribution: Ubiquitous expression of catalytic subunit in all cells and tissue types, while expression of p35 is restricted mainly to neurons.
Function: CDK5 plays important roles in almost all aspects of brain development and function; it regulates multiple players required for axon formation and regeneration.
Interaction: CDK5R1 (p25), CDK5R1 (p35), CDK5RAP1, CDK5RAP2, CDK5RAP3, CABLES1, ABL1, CABLES1, CABLES2, AATK, GSTP1, HDAC1, beta-catenin/CTNNB1, delta-catenin/CTNND2, APEX1, P53/TP53, EPHA4, NGEF, EPHA4, PTK2/FAK1, CLOCK and HTR6.
Ligand/Receptor: CDK5R1 and CDK5R2.
Biology Area: Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Cell Proliferation and Viability, Immunology, Mitochondrial Function, Neuroscience, Neuroscience Cell Markers, Protein Synthesis, Signal Transduction, Synaptic Biology, Transcription Factors
Molecular Family: Postsynaptic proteins, Protein Kinases/Phosphatase
Antigen References: 1. Wilkaniec A, et al. 2015. J. Neurochem. 10.1111/jnc.13365.
2. Liu SL, et al. 2015. Mol. Neurobiol.
3. Lai KO, et al. 2015. Mini. Rev. Med. Chem. 15:390.
4. Ye T, et al. 2012. Int. Rev. Neurobiol. 105:91.
5. Cheung ZH, et al. 2012. Trends Cell Biol. 22:169.
6. Lalioti V, et al. 2010. Cell Cycle 9:284.
7. Slevin M, et al. 2009. Curr. Opin. Pharmacol. 9:119.
8. Dhavan R, et al. 2001. Nat. Rev. Mol. Cell. Biol. 2:749.
9. Pareek TK, et al. 2010. J. Exp. Med. 207:2507.
Gene ID: 1020 View all products for this Gene ID
UniProt: View information about CDK5 on UniProt.org

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