Purified anti-Chk2 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 3864	1

规格

价格

库存

100µg

￥ 3864

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant fragment of Chk2 (AA: 481-531) expressed in E.Coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
ICC, KO/KD-WB - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 ?g/ml.?For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2616885 (BioLegend Cat. No. 686602)

Structure: 543 amino acid with a predicted molecular weight of 61 kD. There are 13 predicted isoforms with MW ranging from 15 to 65KD (15, 17, 19, 23, 24, 26, 32, 36, 38, 50, 58, 61, 65kD, respectively).
Distribution: Nucleus.
Function: Involved in checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks.
Interaction: Homodimer. Interacts with PML, TP53, RB1, BRCA1, MDC1, TP53BP1, CDC25A, CUL1, CDKN2AIP, CCAR2, and SIRT1.
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication
Antigen References: 1. Zannini L, et al. 2014. J. Mol. Cell Biol. 6:442.
2. Matsuoka S, et al. 1998. Science 282:1893.
3. Ahn JY, et al. 2000. Cancer Res. 60:5934.
4. García-Limones C, et al. 2016. Oncogene. doi:10.1038/onc.2015.495.
5. Ta HQ, et al. 2015. Cancer Res. 75:5093.
6. Ertych, et al. 2016. Proc. Natl. Acad. Sci. USA 113:1817.
Gene ID: 11200 View all products for this Gene ID
UniProt: View information about Chk2 on UniProt.org