Alexa Fluor® 594 anti-Chk2 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 2226	1

规格

价格

库存

25µg

￥ 2226

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Purified recombinant fragment of Chk2 (AA: 481-531) expressed in E.Coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 594 under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: ICC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 0.2 - 1.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor? 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.

Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

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RRID: AB_2617020 (BioLegend Cat. No. 686603)

Structure: 543 amino acid with a predicted molecular weight of 61 kD.
Distribution: Nucleus.
Function: Involved in checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks.
Interaction: Homodimer. Interacts with PML, TP53, RB1, BRCA1, MDC1, TP53BP1, CDC25A, CUL1, CDKN2AIP, CCAR2, and SIRT1.
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication
Antigen References: 1. Zannini L, et al. 2014. J. Mol. Cell Biol. 6:442.
2. Matsuoka S, et al. 1998. Science 282:1893.
3. Ahn JY, et al. 2000. Cancer Res. 60:5934.
4. García-Limones C, et al. 2016. Oncogene. doi:10.1038/onc.2015.495.
5. Ta HQ, et al. 2015. Cancer Res. 75:5093.
6. Ertych, et al. 2016. Proc. Natl. Acad. Sci. USA 113:1817.
Gene ID: 11200 View all products for this Gene ID
UniProt: View information about Chk2 on UniProt.org