Biotin anti-Connexin 43, 360-382 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1974	1

Product Details

Verified Reactivity

Human, Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

KLH-conjugated peptide corresponding to amino acids 360-382 of Connexin 43.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

Application

WB - Quality tested
IHC-P - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.01 - 0.1 ?g per ml. For immunohistochemistry, a concentration range of 5.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody binds to the C-terminus of Connexin 43 and shows preference for non-phosphorylated Connexin 43 by western blotting.

Application References (PubMed link indicates BioLegend citation)

Chu G, et al. 2002. Cardiovasc. Res. 54(1):105. (WB)
Wei CJ, et al. 2005. J. Biol. Chem. 280(20):19925. (WB)

RRID

AB_2750331 (BioLegend Cat. No. 849605) AB_2750332 (BioLegend Cat. No. 849606)

Antigen Details

Structure: Connexin 43 (GJA1) is a 382 amino acid protein with a molecular mass of 43 kD.
Distribution: Tissue distribution: Expressed in most tissues, enriched in brain, endocrine, muscle, bone marrow, immune System, ovaries, testes, and Skin.

Cellular distribution: Plasma membrane, cytosol, mitochondria, golgi apparatus, cytoskeleton and endoplasmic reticulum membrane.
Function: Connexin 43 plays a role in cell-to-cell communication by forming channels, or gap junctions between cells. It allows for the transport of nutrients, charged particles (ions), and other small molecules that carry necessary communication signals between cells.
Molecular Family: Gap Junction Proteins
Antigen References: 1. Grek CL,?et al.?2016.?Cancer Lett.?374(1):117.
2. Lilly E,?et al.?2016.?Semin. Cell Dev. Biol.?Feb; 50:4
3. Michela P, et al. 2015. Eur. J. Pharmacol. 768:71-6.
Gene ID: 2697 View all products for this Gene ID
UniProt: View information about Connexin 43 360-382 on UniProt.org

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