Purified anti-CD31 (PECAM-1) Antibody
- 产品名称：
- Purified anti-CD31 (PECAM-1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 910005
- 产品应用：
- 910005
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- The P2B1 monoclonal antibody was generated against IL-1β activated human umbilical vein endothelial cells (HUVECs).
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-F - Quality tested
ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemistry on frozen tissue sections. For immunohistochemistry, a concentration range of 0.5 - 5.0 μg/ml is recommended.?For immunocytochemistry, a concentration range of 1.0 - 2.0 μg/ml (1:250 - 1:500 dilution) is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunofluorescent staining1.
Predicted Molecular Weight = 83 kD
- Application References
(PubMed link indicates BioLegend citation) -
- Brooks PC, et al. 1995. J. Clin. Invest. 96(4):1815. (IF)
- RRID
- AB_2566676 (BioLegend Cat. No. 910005)
- Structure
- 130-140 kD type I transmembrane glycoprotein belonging to the Ig superfamily.
- Distribution
-
Found on the surface of platelets, monocytes, neutrophils, and some types of T-cells. Makes up a large portion of endothelial cell intercellular junctions.
- Function
- Cell adhesion molecule which is required for leukocyte transendothelial migration under most inflammatory conditions. Induces susceptibility to atherosclerosis, member of the immunoglobulin superfamily and is involved in leukocyte migration, angiogenesis, and integrin activation.
- Ligand/Receptor
- CD38
- Cell Type
- Platelets, Monocytes, Neutrophils, T cells
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Neuroinflammation, Neuroscience, Signal Transduction, Synaptic Biology, Transcription Factors
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Tang DG, et al. 1993. J. Biol. Chem. 268(30):22883.
2. Wenzel K, et al. 1999. Hum. Mutat. 14(6):545.
- Gene ID
- 5175 View all products for this Gene ID
- UniProt
- View information about CD31 on UniProt.org
