首页 > 抗体蛋白 > 抗体
Purified anti-AKT1 Antibody
产品名称:
Purified anti-AKT1 Antibody
产品类别:
抗体
产品编号:
680302
产品应用:
680302
[价格]
规格 价格 库存
100µg ¥ 3710 1

产品详情

Product Details

Verified Reactivity
Human, Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Full length recombinant protein of human AKT1 expressed in HEK293T cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
KO/KD-WB -?Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Cataldi S, et al. 2021. Cells. 11:. PubMed
  2. Penas FN, et al. 2020. Front Immunol. 10:2955. PubMed
  3. Cevey ?C, et al. 2021. Front Immunol. 12:782891. PubMed
RRID
AB_2566355 (BioLegend Cat. No. 680302)

Antigen Details

Structure
480 amino acids with a predicted molecular weight of approximately 56 kD.
Distribution

Cytoplasm, nucleus, cell membrane, phosphorylation on Tyr-176 by TNK52 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.

Function
AKT1 plays a key role in regulating cell proliferation, survival, and metabolism.
Interaction
BTBD10, KCTD20, CCDC88A, GRB10, AGAP2, AKTIP, MTCP1, TCL1A , TCL1B, CDKN1B, MAP3K5, BAD, PPP2R5B, STK3, STK4, SIRT1, SRPK2, RAF1, TRIM13, TNK2, CLK2, THEM4 , PDPK1 PA2G4, and KIF14.
Biology Area
Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Neuroscience, Signal Transduction, Ubiquitin/Protein Degradation
Molecular Family
Protein Kinases/Phosphatase
Antigen References

1. Perira L, et al. 2015. Drug Discov. Today 9:1152-8.
2. Yu H, et al. 2015. Vascul. Pharmacol. 71:57-64.
3. Cohen MM Jr. 2013. Am. J. Med. Genet. A. 12:2931-7.
4. Dillon RL, Muller WJ. 2010. Cancer Res. 11:4260-4.
5. Song G, et al. 2005. J. Cell Mol. Med. 1:59-71.
6. Hers I, et al. 2011. Cell Signal. 23:1515.

Gene ID
207 View all products for this Gene ID
UniProt
View information about AKT1 on UniProt.org

联系我们

TEL:021-34661275  点击拨打热线