Purified anti-Beclin-1 Antibody
- 产品名称：
- Purified anti-Beclin-1 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 849701
- 产品应用：
- 849701
- Verified Reactivity
- Human, Rat, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Full length recombinant human Beclin-1 protein (NP_003757) produced in HEK293T cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Deng X, et al. 2017. Biochim. Biophys. Acta. 1862(3):337-350 (WB).
- Product Citations
-
- Rinaldi R, et al. 2021. Cells. 10:. PubMed
- RRID
- AB_2687306 (BioLegend Cat. No. 849701) AB_2687307 (BioLegend Cat. No. 849702)
- Structure
- Beclin-1 is a 450 amino acid protein with a molecular mass of 52 kD.
- Distribution
-
Tissue distribution: Beclin-1 is ubiquitously expressed. Cellular distribution: Cytosol, endoplasmic reticulum, endosome, mitochondria, and nucleus.
- Function
- Beclin-1 is involved in autophagosome formation in autophagy.
- Interaction
- Beclin-1 interacts with Bcl-2 and PI3K class III.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Protein Trafficking and Clearance
- Molecular Family
- Autophagosome Markers
- Antigen References
-
- Cao Y, et al. 2007. Cell. Research 17:839.
- Gene ID
- 8678 View all products for this Gene ID
- UniProt
- View information about Beclin-1 on UniProt.org
