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首页 > 抗体蛋白 > 抗体
Purified anti-ASC Antibody
产品名称：
Purified anti-ASC Antibody
产品类别：
抗体
产品编号：
676502
产品应用：
676502
[价格]
规格 价格 库存
100µg ￥ 4354 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Full length recombinant human PYCARD (NP_037390) produced in E. coli.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Santana DJ, et al. 2020. Curr Protoc Microbiol. 59:e124. PubMed
RRID
AB_2565643 (BioLegend Cat. No. 676502)

Antigen Details

Structure
Full-length ASC (fASC) contains 195 amino acids wtih a predicted molecular weight of 21.6 kD. The sequence of isoform ASC-b is missing 93-111 a.a. The sequence of isoform ASC-c is missing 26-85 a.a.
Distribution

Cytoplasm. In resting monocytes and macrophages, the nucleus is the primary localization.

Function
ASC promotes caspase-mediated apoptosis. This pro-apoptotic activity is mediated predominantly through the activation of caspase-9. ASC is an integral component of the inflammasome. Within the inflammasome, ASC links caspase-1 and NOD-like receptors (NLR), which lead to the activation of caspase-1.
Ligand/Receptor
CIAS1/PYPAF1 and PYDC1.
Cell Type
Dendritic cells
Biology Area
Angiogenesis, Cell Biology, Immunology, Innate Immunity, Neuroscience, Signal Transduction
Antigen References

1. Masumoto J, et al. 1999. J. Biol. Chem. 274:33835.
2. Conway KE, et al. 2000. Cancer Res. 60:6236.
3. Strong R, et al. 1991. Brain Res. 542:23.
4. Srinivasula SM, et al. 2002. J. Biol. Chem. 277:21119.
5. Ohtsuka T, et al. 2004. Nat. Cell Biol. 6:121.
6. Ippagunta SK, et al. 2010. J. Biol. Chem. 285:12454.
7. Liu W, et al. 2013. J. Invest Dermatol. 2:518-527.

Gene ID
29108 View all products for this Gene ID
UniProt
View information about ASC on UniProt.org

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