Purified anti-SNAP-25 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1568	1

Product Details

Verified Reactivity

Human, Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Full-length recombinant human SNAP-25 protein (NP_003072) produced in HEK293T cell.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

WB - Quality tested
IHC-P - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml.?For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Dentoni G, et al. 2022. Cells. 11:. PubMed
Naia L, et al. 2021. BMC Biology. 19(1):57. PubMed

RRID

AB_2715872 (BioLegend Cat. No. 850301) AB_2715873 (BioLegend Cat. No. 850302)

Antigen Details

Structure: SNAP-25 is a 206 amino acid protein with a molecular mass of 23 kD.
Distribution: Tissue distribution: Mainly in the central nervous system, in neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei and granule cells of the cerebellum.
Cellular distribution: Cytosol, golgi apparatus and cell membrane.
Function: SNAP-25 associates with proteins involved in vesicle docking and membrane fusion. It regulates plasma membrane recycling through its interaction with centromere protein F (CENPF).
Interaction: SNAP-25 has been found to be part of the SNARE core complex containing SNAP25, VAMP2 and STX1A). SNAP-25 was also found in a complex containing SYT1, SV2B and syntaxin-1. SNAP-25 interacts with KCNB1 (via N-terminus), which reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. In developing brain and cell cultures, SNAP-25 reacts with neuronal cell bodies and axons. It is useful as an early marker for developing neurons in cell culture.
Cell Type: Mesenchymal Stem Cells, Neurons
Biology Area: Cell Biology, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family: Presynaptic proteins
Antigen References: 1. Egbujo CN, et al. 2016. Curr. Psychiatry Rep. 18(8):77.
2. Antonucci F, et al. 2016. Front. Synaptic Neurosci. 8:7.
3. Cupertino RB, et al. 2016. J. Neural. Transm. (Vienna). 123(8):867.
Gene ID: 6616 View all products for this Gene ID
UniProt: View information about SNAP-25 on UniProt.org

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