Alexa Fluor® 647 anti-mouse CD146 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 4102	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Rat

Immunogen

Endothelial cell line TME-3H3

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 647 under optimal conditions.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested
IHC-F, 3D IHC - Verified

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per million cells in 100 ?l volume.?For immunohistochemistry, a concentration range of 5.0 - 10.0 ?g/ml is suggested. For 3D immunohistochemistry on formalin-fixed tissues, a concentration of 5.0 ?g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor? 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.

Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

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Excitation Laser

Red Laser (633 nm)

Application References (PubMed link indicates BioLegend citation)

Schrage A, et al. 2008. Histochem. Cell. Biol. 129:441.
Birbrair A, et al. 2013. Am J Physiol Cell Physiol. 305:1098. PubMed

Product Citations

Zhu Q, et al. 2022. Atherosclerosis. 357:41. PubMed

RRID

AB_2721426 (BioLegend Cat. No. 134717) AB_2721427 (BioLegend Cat. No. 134718)

Antigen Details

Structure: CD146 is a transmembrane glycoprotein and belongs to the Ig superfamily of cell adhesion molecules.
Distribution: CD146 is strongly expressed by murine vascular endothelial cells, a subset of NK1.1⁺ cells, and neutrophils.
Function: CD146 has been reported to be functionally relevant for endothelial cell adhesion, angiogenesis, and NK cell function.
Ligand/Receptor: Unidentified ligand.
Cell Type: Endothelial cells, Mesenchymal Stem Cells, Neutrophils
Biology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Despoix N, et al. 2008. Eur. J. Immunol. 38:2855.
2. Sorrentino A, et al. 2008. Exp. Hematol. 36:1035.
3. Bardin N, et al. 2009. Arterioscler. Thromb. Vasc. Biol. 29:746.
Gene ID: 84004 View all products for this Gene ID
UniProt: View information about CD146 on UniProt.org

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