APC anti-human CD271 (NGFR) Antibody
- 产品名称：
- APC anti-human CD271 (NGFR) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 345107
- 产品应用：
- 345107
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 2156 |
1 |
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- WM245 melanoma cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications for the relevant formats include: immunoprecipitation1, Western blotting4, immunohistochemical staining of frozen or paraffin embedded tissue sections1,2, and blocking of NGF binding1.
- Application References
(PubMed link indicates BioLegend citation) -
- Ross A, et al. 1984. P. Natl. Acad. Sci. USA 81:6681. (FC, IP, Block, IHC)
- Cattoretti G, et al. 1993. Blood 81:1726. (IHC)
- Kamke MR, et al. 2005. Hear Res. 206:89.
- Baker D, et al. 1989. Cancer Res. 49:4142-4146. (FC, WB)
- Product Citations
-
- Peng K, et al. 2020. Sci Rep. 10:18433. PubMed
- Torre E et al. 2018. Cell systems. 6(2):171-179 . PubMed
- Torre EA, et al. 2021. Nat Genet. 53:76. PubMed
- Fahl SP, et al. 2018. J Immunol. 200:3450. PubMed
- Giambra V et al. 2018. Cell stem cell. 23(5):714-726 . PubMed
- Gu P, et al. 2016. Oncogene. 10.1038/onc.2016.405. PubMed
- Brun J, et al. 2015. PLoS One. 10: 0145153. PubMed
- Greenwood EJD et al. 2019. Cell Rep. 27(5):1579-1596 . PubMed
- Berical A, et al. 2022. Nat Commun. 13:4270. PubMed
- Leibel SL, et al. 2022. iScience. 25:103797. PubMed
- Duan X, et al. 2022. Cell Biosci. 12:60. PubMed
- Kumar B, et al. 2022. Sci Adv. 8:eabh3375. PubMed
- Stowe CL, et al. 2019. eLife. 0.333333333333333. PubMed
- Jiang M, et al. 2021. Developmental Cell. 56(11):1646-1660.e5. PubMed
- Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
- Portillo AL, et al. 2021. STAR Protoc. 2:100956. PubMed
- Bazot Q, et al. 2014. Nucleic Acids Res. 42:9700. PubMed
- Suzuki S, et al. 2021. STAR Protocols. 2(3):100683. PubMed
- Loo CS, et al. 2020. Immunity. 53:143. PubMed
- Barbarani G, et al. 2019. Sci Rep. 9:3388. PubMed
- Shalabi SF, et al. 2021. Nat Aging. 1:838. PubMed
- Kumar B, et al. 2018. Cancer Res. 78:5107. PubMed
- Hawkins FJ, et al. 2020. Cell Stem Cell. 28(1):79-95.e8. PubMed
- Shin B, et al. 2020. Cell Rep. 1898:30. PubMed
- Hu Y, et al. 2016. J Exp Med. 213: 2759 - 2772. PubMed
- Portillo AL, et al. 2021. iScience. 24(6):102619. PubMed
- Boshuizen J, et al. 2020. Nat Commun. 3.198611111. PubMed
- Rodrigues Toste de Carvalho AL, et al. 2021. Nat Protoc. 16:1802. PubMed
- RRID
- AB_10639737 (BioLegend Cat. No. 345107) AB_10645515 (BioLegend Cat. No. 345108)
- Structure
- Type I transmembranal protein with a MW of 75 kD. The extracellular portion contains four TNFR-Cys repeats that form the NGF binding domain; the intracellular portion contains a death domain.
- Distribution
-
Expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells, melanocytes.
- Function
- Apoptosis, differentiation, neurogenesis.
- Interaction
- TRAF2, TRAF4, TRAF6, PTPN13, RANBP9.
- Ligand/Receptor
- Nerve growth factor (NGF), Brain-derived neurotrophic factor (BDNF), Neurotrophin 3. (NTF3) , Neurotrophin 4 (NTF4)
- Bioactivity
- Apoptosis, differentiation, neurogenesis.
- Cell Type
- Dendritic cells, Mesenchymal cells, Mesenchymal Stem Cells, Neurons
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Neuroscience, Stem Cells, Synaptic Biology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, Postsynaptic proteins
- Antigen References
-
1. Friedman MJ, et al. 2009. J. Biol. Chem. 284:27944.
2. Rock JR, et al. 2009. Proc Natl Acad Sci USA. 106:12771.
3. Kidd SK, et al. 2008. Brain Res.1195:113.
4. Peters EM, et al. 2007. Am J Pathol. 171:1872.
5. Jansen P, et al. 2007. Nat Neurosci. 10:1449.
- Gene ID
- 4804 View all products for this Gene ID
- UniProt
- View information about CD271 on UniProt.org
