APC anti-mouse CD146 Antibody
- 产品名称：
- APC anti-mouse CD146 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 134711
- 产品应用：
- 134711
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Endothelial cell line TME-3H3
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Schrage A, et al. 2008. Histochem. Cell. Biol. 129:441.
- Birbrair A, et al. 2013. Am J Physiol Cell Physiol. 305:1098. PubMed
- Product Citations
-
- Grosse L, et al. 2020. Cell Metabolism. 32(1):87-99.e6. PubMed
- Bonnardel J, et al. 2019. Immunity. 51:638. PubMed
- Bachofner M, et al. 2017. Dev Cell. 42:616. PubMed
- Xiong X et al. 2019. Mol Cell. 75(3):644-660 . PubMed
- Gentek R, et al. 2018. Immunity. 48:1160. PubMed
- Yang Z, et al. 2020. J Invest Dermatol. 544:140. PubMed
- Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
- Thomson CA, et al. 2018. J Immunol. 201:215. PubMed
- Han Y, et al. 2019. J Clin Invest. 130:26. PubMed
- RRID
- AB_2563087 (BioLegend Cat. No. 134711) AB_2563088 (BioLegend Cat. No. 134712)
- Structure
- CD146 is a transmembrane glycoprotein and belongs to the Ig superfamily of cell adhesion molecules.
- Distribution
-
CD146 is strongly expressed by murine vascular endothelial cells, a subset of NK1.1+ cells, and neutrophils.
- Function
- CD146 has been reported to be functionally relevant for endothelial cell adhesion, angiogenesis, and NK cell function.
- Ligand/Receptor
- Unidentified ligand.
- Cell Type
- Endothelial cells, Mesenchymal Stem Cells, Neutrophils
- Biology Area
- Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Despoix N, et al. 2008. Eur. J. Immunol. 38:2855.
2. Sorrentino A, et al. 2008. Exp. Hematol. 36:1035.
3. Bardin N, et al. 2009. Arterioscler. Thromb. Vasc. Biol. 29:746.
- Gene ID
- 84004 View all products for this Gene ID
- UniProt
- View information about CD146 on UniProt.org
