Biotin anti-mouse CD262 (DR5, TRAIL-R2) Antibody
- 产品名称：
- Biotin anti-mouse CD262 (DR5, TRAIL-R2) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 119904
- 产品应用：
- 119904
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- Mouse DR5-Ig fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: in vitro and in vivo induction of cytotoxicity2,3. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 119909).
- Application References
(PubMed link indicates BioLegend citation) -
- Hayakawa Y, et al. 2004. J. Immunol. 172:123. (FC)
- Takeda K, et al. 2004. J. Exp. Med. 199:437. (Cyt)
- Sato K, et al. 2005. J. Immunol. 174:4025. (Cyt)
- Iannello A, et al. 2009. J. Virol. 83:5999. PubMed
- Grisendi G, et al. 2010. Cancer Res. 70:3718. PubMed
- RRID
- AB_345400 (BioLegend Cat. No. 119904)
- Structure
- Type I transmembrane protein, TNF receptor superfamily member, homotrimer, predicted molecular weight 55 kD
- Distribution
-
Widely expressed in normal tissues and some tumor cell lines. Expression regulated by the tumor suppressor p53
- Function
- Binds to TRAIL, activates NF- ?B, induces apoptosis. May be involved in the regulation of tumor metastases.
- Ligand/Receptor
- TRAIL (CD253); cytoplasmic domain interacts with TRADD and RIP
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Wu GS, et al. 1999. Cancer Res. 59:2770.
- Gene ID
- 21933 View all products for this Gene ID
- UniProt
- View information about CD262 on UniProt.org
