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PE anti-human CD3 Antibody
产品名称：
PE anti-human CD3 Antibody
产品类别：
抗体
产品编号：
300307
产品应用：
300307
[价格]
规格 价格 库存
25tests ￥ 392 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported (for the relevant formats) applications include: immunohistochemical staining of acetone-fixed frozen sections, immunoprecipitation, and activation of T lymphocytes4-7. The HIT3a antibody is able to stimulate T cell activation. The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 300314). For highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. No. 300332) with a lower endotoxin limit than standard LEAF? purified antibodies (Endotoxin <0.01 EU/?g).

Application References

(PubMed link indicates BioLegend citation)
  1. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
  2. Knapp W. 1989. Leucocyte Typing IV. Oxford University Press New York.
  3. Barclay N, et al. 1997. The Leucocyte Antigen Facts Book. Academic Press Inc. San Diego.
  4. Sedelies KA, et al. 2004. J. Biol. Chem. 279:26581. (Activ)
  5. Rivollier A, et al. 2004. Blood 104:4029. (Activ)
  6. Scharschmidt E, et al. 2004. Mol. Cell Biol. 24:3860. (Activ)
  7. Smeltz RB. 2007. J. Immunol. 178:4786. (Activ)
  8. Enghard P, et al. 2014. Ann Rheum Dis. 73:277. PubMed
Product Citations
  1. Wu Y, et al. 2021. Cancer Gene Ther. Online ahead of print. PubMed
  2. Wang H, et al. 2020. J Exp Clin Cancer Res. 39:29. PubMed
  3. Lin GL, et al. 2018. Acta Neuropathol Commun. 9:617. PubMed
  4. Rochat MA, et al. 2018. Virol J. 15:191. PubMed
  5. Bardet M, et al. 2018. Immunol Cell Biol. 96:81. PubMed
  6. Galindo-Albarrán A, et al. 2016. Cell Rep. 17:2151-2160. PubMed
  7. Liu F, et al. 2020. Oncoimmunology. 9:1746573. PubMed
  8. Enghard P, et al. 2014. Ann Rheum Dis. 73:277. PubMed
  9. Kokkinopoulos I, et al. 2021. Sci Rep. 11:15759. PubMed
  10. Ma C, et al. 2021. Signal Transduct Target Ther. 6:353. PubMed
  11. Wu M, et al. 2021. Nat Commun. 12:3500. PubMed
  12. Wu W, et al. 2020. Oncol Lett. 0.91875. PubMed
  13. Blandine Monel et al. 2019. Cell reports. 27(1):142-153 . PubMed
  14. Park JA, et al. 2021. Journal for ImmunoTherapy of Cancer. 9(5):. PubMed
  15. González-Jiménez A, et al. 2022. Int J Mol Sci. 23:. PubMed
  16. Jackson-Jones LH, et al. 2020. Immunity. 52:700. PubMed
  17. Tuganbaev T, et al. 2020. Cell. 182(6):1441-1459.e21. PubMed
  18. Pellegrini JM, et al. 2021. Sci Rep. 11:13559. PubMed
  19. Brown CC, et al. 2020. Cell. 179(4):846-863.e24.. PubMed
  20. Woodberry T, et al. 2017. Infect Immun. 85:e00986. PubMed
  21. Pereira PMR, et al. 2022. Nat Commun. 13:2526. PubMed
  22. Kacherovsky N, et al. 2019. Nat Biomed Eng. 0.66875. PubMed
  23. Liu J, et al. 2021. Medicine (Baltimore). 100:e24619. PubMed
  24. Joly P, et al. 2017. PLoS One. 12(6):e0180568. PubMed
  25. Usmani SM et al. 2019. Cell host & microbe. 25(1):73-86 . PubMed
  26. Mori A, et al. 2021. Cells. :10. PubMed
  27. Chulpanova DS, et al. 2021. Biology (Basel). 10:. PubMed
  28. Platten M, et al. 2021. Nature. 592:463. PubMed
  29. Valestrand L, et al. 2022. Am J Pathol. . PubMed
  30. Park JA, et al. 2020. J Hematol Oncol. 0.661111111. PubMed
  31. Cheng J, et al. 2021. Biomed Res Int. 2021:6614784. PubMed
  32. Lai Y, et al. 2022. Clin Transl Med. 12:e999. PubMed
  33. Wei J, et al. 2019. J Immunother Cancer. 7:209. PubMed
  34. Mujib S, et al. 2017. JCI Insight. 2:e93687. PubMed
  35. ?yszkiewicz M, et al. 2020. Nat Commun. 11:1031. PubMed
  36. Wang X, et al. 2022. J Exp Clin Cancer Res. 41:210. PubMed
  37. Hu JQ, et al. 2020. J Cancer. 3.409722222. PubMed
  38. Zhai Y, et al. 2018. Autophagy. 1.714583333. PubMed
  39. Pekayvaz K, et al. 2022. Nat Commun. 13:1018. PubMed
  40. Ma S, et al. 2022. Nat Commun. 13:4118. PubMed
RRID
AB_314043 (BioLegend Cat. No. 300307) AB_314044 (BioLegend Cat. No. 300308)

Antigen Details

Structure
Ig superfamily, with the subunits of CD3γ, CD3δ, CD3ζ (CD247) and TCR (α/β or γ/δ) forms CD3/TCR complex, 20 kD
Distribution

Mature T and NK-T cells, thymocyte differentiation

Function
Antigen recognition, signal transduction, T cell activation
Ligand/Receptor
Peptide antigen bound to MHC
Cell Type
T cells, NKT cells, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules, TCRs
Antigen References

1. Barclay N, et al. 1993. The Leucocyte FactsBook. Academic Press. San Diego.
2. Beverly P, et al. 1981. Eur. J. Immunol. 11:329.
3. Lanier L, et al. 1986. J. Immunol. 137:2501-2507.

Gene ID
916 View all products for this Gene ID
UniProt
View information about CD3 on UniProt.org

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