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Brilliant Violet 510™ anti-human CD19 Antibo
产品名称：
Brilliant Violet 510™ anti-human CD19 Antibo
产品类别：
抗体
产品编号：
302241
产品应用：
302241
[价格]
规格 价格 库存
25tests ￥ 2548 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 510? under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Brilliant Violet 510? excites at 405 nm and emits at 510 nm. The bandpass filter 510/50 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 510? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections8 and blocking of B cell proliferation. Clone HIB19 is not recommended for formalin-fixed paraffin-embedded sections. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 302267 & 302268).

?

Clone HIB19 partially blocks anti-human CD19 clones 4G7 and SJ25C1 staining based on in-house testing

Application References

(PubMed link indicates BioLegend citation)
  1. Schlossman S, et al. 1995. Leucocyte Typing V. Oxford University Press. New York.
  2. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
  3. Bradbury L, et al. 1993. J. Immunol. 151:2915.
  4. Joseph A, et al. 2010. J. Virol. 84:6645. PubMed
  5. Wang X, et al. 2010. Haematologica. 95:884. (FC) PubMed
  6. Walker JD, et al. 2009. J. Immunol. 182:1548. (Block) PubMed
  7. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  8. Hansen A, et al. 2002. Arthritis Rheum. 46:2160. (IHC)
  9. Stoeckius M, et al. 2017. Nat. Methods. 14:865. (PG)
  10. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
Product Citations
  1. Krummey SM, et al. 2020. Cell Reports. 30(5):1282-1291.e5.. PubMed
  2. Lagou V et al. 2018. Cell reports. 25(3):798-810 . PubMed
  3. Sannier G, et al. 2021. Cell Reports. 36(9):109643. PubMed
  4. Eslamizar L, et al. 2021. NPJ Vaccines. 6:15. PubMed
  5. Li C, et al. 2022. J Exp Med. 219:. PubMed
  6. Martrus G, et al. 2017. PLoS One.. 10.1371/journal.pone.0182532. PubMed
  7. Schlicher L, et al. 2022. Int J Mol Sci. 23:. PubMed
  8. Gro? R, et al. 2022. EBioMedicine. 75:103761. PubMed
  9. Kokkinopoulos I, et al. 2021. Sci Rep. 11:15759. PubMed
  10. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  11. Weisberg SP, et al. 2020. Cell Reports. 29(12):3916-3932.e5.. PubMed
  12. Catapano M, et al. 2020. J Invest Dermatol. 140:816. PubMed
  13. Romero-Olmedo AJ, et al. 2022. Nat Microbiol. 7:195. PubMed
  14. Demers K, et al. 2016. PLoS Pathog. 12: 1005805. PubMed
  15. Pape KA, et al. 2021. Cell Rep. 37:109823. PubMed
  16. Kuri-Cervantes L, et al. 2020. STAR Protoc. 1:100154. PubMed
  17. Hu EY, et al. 2021. Blood Adv. 5:3152. PubMed
  18. van der Ploeg K, et al. 2022. Cell Rep Med. 3:100640. PubMed
  19. Caduff N, et al. 2021. Cell Reports. 35(5):109056. PubMed
  20. Yarmarkovich M, et al. 2021. Nature. 599:477. PubMed
  21. Bonifacius A, et al. 2021. Immunity. 54(2):340-354.e6. PubMed
  22. Rutishauser L, et al. 2017. AIDS Res Hum Retroviruses . 10.1089/AID.2016.0324. PubMed
  23. B?cker-Koduah P, et al. 2020. Ann Clin Transl Neurol. 1.422222222. PubMed
  24. Silver J, et al. 2020. Methods Mol Biol. 2121:115. PubMed
  25. Bradley T et al. 2018. Cell. 175(2):387-399 . PubMed
  26. Hu EY, et al. 2020. JCI Insight. 5:00. PubMed
  27. Buggert M, et al. 2020. Cell. 183(7):1946-1961.e15. PubMed
  28. Tong P, et al. 2021. Cell. :. PubMed
  29. Pape KA, et al. 2022. JCI Insight. 7:. PubMed
  30. Morris AB, et al. 2020. Immunity. 52(1):136-150.e6.. PubMed
  31. Pucino V, et al. 2020. Cell Metabolism. 30(6):1055-1074.e8.. PubMed
  32. Shih T, et al. 2019. Front Immunol. 10:1652. PubMed
  33. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  34. Peluso MJ, et al. 2021. Cell Rep. 36:109518. PubMed
  35. Cohen CA, et al. 2021. Nat Commun. 12:4678. PubMed
  36. Moguche AO et al. 2017. Cell host & microbe. 21(6):695-706 . PubMed
  37. Rakshit S, et al. 2020. Cell Rep. 33:108451. PubMed
  38. Mudd PA, et al. 2022. Cell. 185:603. PubMed
  39. Sekine T, et al. 2020. Cell. 183:158. PubMed
  40. Sagebiel AF, et al. 2019. Nat Commun. 10:975. PubMed
  41. Ruella M, et al. 2018. Nat Med. 24:1499. PubMed
  42. NULL, et al. 2022. Cell. 185:916. PubMed
  43. Chen Y, et al. 2020. Cell. 1496:183. PubMed
  44. Baxter AE, et al. 2017. Nat Protoc. 12:2029. PubMed
  45. Danzer H, et al. 2020. Elife. 9:00. PubMed
  46. Sung JA, et al. 2018. Mol Ther. 26:2496. PubMed
  47. Abd Hamid M et al. 2019. Cancer Immunol Res. 7(8):1293-1306 . PubMed
  48. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  49. Giron LB, et al. 2020. EBioMedicine. 73.94791667. PubMed
  50. Vanderbeke L, et al. 2021. Nat Commun. 12:4117. PubMed
  51. Upasani V, et al. 2019. Front Immunol. 2.152777778. PubMed
  52. Gamradt S, et al. 2021. iScience. 24:103312. PubMed
RRID
AB_2561381 (BioLegend Cat. No. 302241) AB_2561668 (BioLegend Cat. No. 302242)

Antigen Details

Structure
Ig superfamily, type I transmembrane glycoprotein, 95 kD
Distribution

B lineage (except plasma cells), follicular dendritic cells

Function
B cell activation and differentiation
Ligand/Receptor
Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor
Cell Type
B cells, Dendritic cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Tedder T, et al. 1994. Immunol. Today 15:437.
2. Bradbury L, et al. 1993. J. Immunol. 151:2915.

Gene ID
930 View all products for this Gene ID
UniProt
View information about CD19 on UniProt.org

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