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Brilliant Violet 421™ anti-human CD19 Antibo
产品名称：
Brilliant Violet 421™ anti-human CD19 Antibo
产品类别：
抗体
产品编号：
302233
产品应用：
302233
[价格]
规格 价格 库存
25tests ￥ 2660 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421? under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
ICC, IHC-F - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?L?per million cells in 100 ?L?staining volume or 5 ?L?per 100 ?L?of whole blood. For immunohistochemical staining on frozen tissue sections, the suggested use of this reagent is 5.0 - 10 ?g per mL. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 421? excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections8 and blocking of B cell proliferation. Clone HIB19 is not recommended for formalin-fixed paraffin-embedded sections. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 302267 & 302268).

?

Clone HIB19 partially blocks anti-human CD19 clones 4G7 and SJ25C1 staining based on in-house testing

Application References

(PubMed link indicates BioLegend citation)
  1. Schlossman S, et al. 1995. Leucocyte Typing V. Oxford University Press. New York.
  2. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
  3. Bradbury L, et al. 1993. J. Immunol. 151:2915.
  4. Joseph A, et al. 2010. J. Virol. 84:6645. PubMed
  5. Wang X, et al. 2010. Haematologica. 95:884. (FC) PubMed
  6. Walker JD, et al. 2009. J. Immunol. 182:1548. (Block) PubMed
  7. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  8. Hansen A, et al. 2002. Arthritis Rheum. 46:2160. (IHC)
  9. Stoeckius M, et al. 2017. Nat. Methods. 14:865. (PG)
  10. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
Product Citations
  1. Sajadi MM, et al. 2018. Cell. 173:1783. PubMed
  2. Hohmann MS, et al. 2021. JCI Insight. 6:. PubMed
  3. De Hert E, et al. 2022. Int J Mol Sci. 23:. PubMed
  4. Nakano M, et al. 2021. Front Immunol. 12:713225. PubMed
  5. Pholcharee T, et al. 2021. Nat Commun. 12:1063. PubMed
  6. O’Connor K, et al. 2016. Genes Immun. 10.1038/gene.2016.27. PubMed
  7. Panwar B, et al. 2021. Genome Res. 31:659. PubMed
  8. Turner JS, et al. 2021. Nature. 596:109. PubMed
  9. Sun Q, et al. 2022. Cell Death Dis. 13:724. PubMed
  10. Travaglini KJ, et al. 2020. Nature. 587:619. PubMed
  11. Mimitou EP, et al. 2021. Nat Biotechnol. 39:1246. PubMed
  12. Vijayakumar B, et al. 2022. Immunity. . PubMed
  13. Frensch M, et al. 2021. Cell Mol Life Sci. 78:8165. PubMed
  14. Wouters K, et al. 2017. Sci Rep. 7:42665. PubMed
  15. Koppejan H, et al. 2019. Arthritis Res Ther. 21:03. PubMed
  16. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  17. Rohner L, et al. 2020. Sci Rep. 0.570833333. PubMed
  18. Singh M, et al. 2020. Cell. 180(5):878-894. PubMed
  19. Caeser R, et al. 2021. Nat Protoc. 16:2499. PubMed
  20. Studniberg SI, et al. 2022. Mol Syst Biol. 18:e10824. PubMed
  21. Zumaquero E, et al. 2019. Elife. 8. PubMed
  22. Shih T, et al. 2019. Front Immunol. 10:1652. PubMed
  23. Rossignol ED, et al. 2021. Cell Reports. 35(8):109167. PubMed
  24. Tan Y, et al. 2014. Cell Immunol. 151:55. PubMed
  25. NULL, et al. 2020. J Clin Immunol. 40:1. PubMed
  26. De Silva TI, et al. 2021. iScience. 24:103353. PubMed
  27. Schoofs T et al. 2019. Immunity. 50(6):1513-1529 . PubMed
  28. Usmani SM et al. 2019. Cell host & microbe. 25(1):73-86 . PubMed
  29. Cizmeci D, et al. 2021. eLife. 10:00. PubMed
  30. Ju CH, et al. 2018. Clin Immunol. 193:70. PubMed
  31. Antonarakis ES, et al. 2018. Clin Cancer Res. 24:4662. PubMed
  32. Verboven K, et al. 2018. Sci Rep. 8:4677. PubMed
  33. Turner JS, et al. 2020. Nature. 586:127. PubMed
  34. Hegewisch-Solloa E, et al. 2021. J Immunol. 207:950. PubMed
  35. Setliff I, et al. 2018. Cell Host Microbe. 23:845. PubMed
  36. Amara K, et al. 2017. J Autoimmun. 10.1016/j.jaut.2017.03.004. PubMed
  37. Zheng H, et al. 2022. Cell Rep. 39:110864. PubMed
  38. Lu D, et al. 2014. Cell Immunol. 152:77. PubMed
  39. Baguma R, et al. 2017. PLoS One. 10.1371/journal.pone.0184563. PubMed
  40. Tian P, et al. 2022. Front Cell Dev Biol. 10:835321. PubMed
RRID
AB_10897802 (BioLegend Cat. No. 302233) AB_11142678 (BioLegend Cat. No. 302234)

Antigen Details

Structure
Ig superfamily, type I transmembrane glycoprotein, 95 kD
Distribution

B lineage (except plasma cells), follicular dendritic cells

Function
B cell activation and differentiation
Ligand/Receptor
Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor
Cell Type
B cells, Dendritic cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Tedder T, et al. 1994. Immunol. Today 15:437.
2. Bradbury L, et al. 1993. J. Immunol. 151:2915.

Gene ID
930 View all products for this Gene ID
UniProt
View information about CD19 on UniProt.org

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