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APC/Cyanine7 anti-human CD19 Antibody
产品名称：
APC/Cyanine7 anti-human CD19 Antibody
产品类别：
抗体
产品编号：
302217
产品应用：
302217
[价格]
规格 价格 库存
25tests ￥ 2142 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The CD19 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections8 and blocking of B cell proliferation. Clone HIB19 is not recommended for formalin-fixed paraffin-embedded sections. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 302267 & 302268).

?

Clone HIB19 partially blocks anti-human CD19 clones 4G7 and SJ25C1 staining based on in-house testing

Additional Product Notes

BioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.

Application References

(PubMed link indicates BioLegend citation)
  1. Schlossman S, et al. 1995. Leucocyte Typing V. Oxford University Press. New York.
  2. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
  3. Bradbury L, et al. 1993. J. Immunol. 151:2915.
  4. Joseph A, et al. 2010. J. Virol. 84:6645. PubMed
  5. Wang X, et al. 2010. Haematologica. 95:884. (FC) PubMed
  6. Walker JD, et al. 2009. J. Immunol. 182:1548. (Block) PubMed
  7. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  8. Hansen A, et al. 2002. Arthritis Rheum. 46:2160. (IHC)
  9. Stoeckius M, et al. 2017. Nat. Methods. 14:865. (PG)
  10. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
Product Citations
  1. Chabi S, et al. 2020. Cell Reports. 29(8):2307-2320.e6.. PubMed
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  4. Woo MS, et al. 2021. iScience. 24(7):102752. PubMed
  5. Shoda H, et al. 2017. Arthritis Research & Therapy . 10.1186/s13075-017-1308-y. PubMed
  6. Pan YG, et al. 2022. Methods Mol Biol. 2574:31. PubMed
  7. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  8. Andonian BJ, et al. 2022. Sci Rep. 12:7450. PubMed
  9. Pozzetto B, et al. 2021. Nature. 600:701. PubMed
  10. Yamauchi T et al. 2018. Cancer cell. 33(3):386-400 . PubMed
  11. Novakova L et al. 2018. Journal of neurochemistry. 146(3):322-332 . PubMed
  12. Deng C, et al. 2016. Diabetes Care. 39: 434 - 440. PubMed
  13. Li H, et al. 2016. J Immunol. 196: 4064 - 4074. PubMed
  14. Nagafuchi Y, et al. 2016. Sci Rep. 6:29338. PubMed
  15. Tsuchida Y, et al. 2017. PLoS One. 10.1371/journal.pone.0169646. PubMed
  16. Li Y, et al. 2021. Nat Commun. 12:87. PubMed
  17. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  18. AC Belkina, JE Snyder-Cappione 2017. Cytometry A. 91:175-179. PubMed
  19. Wang H, et al. 2022. iScience. 25:105065. PubMed
  20. Zhou Y, et al. 2017. Front Cell Infect Microbiol. 7:457. PubMed
  21. Pan YG, et al. 2021. Immunity. 54(6):1245-1256.e5. PubMed
  22. Kreutmair S, et al. 2021. Immunity. . PubMed
  23. Golovkin A, et al. 2021. Viruses. 13:. PubMed
  24. Frensch M, et al. 2021. Cell Mol Life Sci. 78:8165. PubMed
  25. Zhang X, et al. 2021. Front Immunol. 12:680068. PubMed
  26. Coelho CH, et al. 2020. JCI Insight. 5:. PubMed
  27. Neff CP et al. 2018. EBioMedicine. 30:192-202 . PubMed
  28. Kuebler P, et al. 2015. Proc Natl Acad Sci U S A. 112: 8379 - 8384. PubMed
  29. Sinha D, et al. 2021. J Immunother Cancer. 9:. PubMed
  30. Punik J, et al. 2021. Cell Reports. 35(13):109320. PubMed
  31. Kudryavtsev IV, et al. 2021. Curr Issues Mol Biol. 44:194. PubMed
  32. Urlaub D, et al. 2019. Arthritis Res Ther. 1.067361111. PubMed
  33. Martín–Gayo E, et al. 2020. Cell Rep. 30:984. PubMed
  34. Arcangeli S, et al. 2022. J Clin Invest. 132:. PubMed
  35. Pahl MC, et al. 2022. Genome Biol. 23:125. PubMed
  36. James KR, et al. 2020. Nat Immunol. 1.113194444. PubMed
  37. Herati RS, et al. 2021. Cell Reports Medicine. 2(5):100262. PubMed
  38. Sefik E, et al. 2021. Nat Biotechnol. . PubMed
  39. Joseph A, et al. 2010. J Virol. 84:6645. PubMed
  40. Sitlinger A, et al. 2021. Cells. 10:. PubMed
  41. Samarani S, et al. 2020. Mediators Inflamm. 2020:6401969. PubMed
  42. Valestrand L, et al. 2022. Am J Pathol. . PubMed
  43. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  44. Turaj AH et al. 2017. Cancer cell. 32(6):777-791 . PubMed
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  50. K?rner C et al. 2017. Cell host & microbe. 22(1):111-119 . PubMed
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  52. Breton G, et al. 2015. J Exp Med. 212:401. PubMed
  53. Suzuki D, et al. 2020. Stem Cell Reports. 14:49. PubMed
  54. Sander J et al. 2017. Immunity. 47(6):1051-1066 . PubMed
  55. Shehata L, et al. 2019. Nat Commun. 10:1126. PubMed
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RRID
AB_314247 (BioLegend Cat. No. 302217) AB_314248 (BioLegend Cat. No. 302218)

Antigen Details

Structure
Ig superfamily, type I transmembrane glycoprotein, 95 kD
Distribution

B lineage (except plasma cells), follicular dendritic cells

Function
B cell activation and differentiation
Ligand/Receptor
Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor
Cell Type
B cells, Dendritic cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Tedder T, et al. 1994. Immunol. Today 15:437.
2. Bradbury L, et al. 1993. J. Immunol. 151:2915.

Gene ID
930 View all products for this Gene ID
UniProt
View information about CD19 on UniProt.org

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