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首页 > 抗体蛋白 > 抗体
PE anti-p53 Antibody
产品名称：
PE anti-p53 Antibody
产品类别：
抗体
产品编号：
645805
产品应用：
645805
[价格]
规格 价格 库存
25tests ￥ 2044 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
p53 N-terminal linear epitope aa 20-25
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Vojtesek B, et al. 1992. J. Immunol. Methods 151:237.
  2. Stephen CW, et al. 1995. J. Mol. Biol. 248:58.
Product Citations
  1. Padalino G, et al. 2021. Eur J Med Chem. 226:113823. PubMed
  2. Catenacci D, et al. 2015. Gastroenterology. 149: 1794-1803.e4. PubMed
RRID
AB_2562267 (BioLegend Cat. No. 645805) AB_2562268 (BioLegend Cat. No. 645806)

Antigen Details

Structure
Tetramer; 53 kD
Distribution

Nuclear when activated

Function
Tumor suppressor, transcription factor regulates cell cycle checkpoint, apoptosis, DNA integrity
Interaction
mdm2, mdmx, TopoI, PML3, Bcl-XL, Bcl-2, Chk1, JNK, p38, HIPK2, CK2, DNA-PK, p300/CBP, PCAF, PARP1, HDAC1-3; mutant p53 associates with p63, p73
Cell Type
Mesenchymal Stem Cells
Biology Area
Cell Biology, DNA Repair/Replication, Stem Cells
Gene ID
7157 View all products for this Gene ID
UniProt
View information about p53 on UniProt.org

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