PE anti-human CD262 (DR5, TRAIL-R2) Antibody
- 产品名称：
- PE anti-human CD262 (DR5, TRAIL-R2) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 307405
- 产品应用：
- 307405
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1876 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Extracellular domain of DR5-human IgG1 Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: The DJR2-4 antibody is useful for immunofluorescent staining and flow cytometric analysis of DR5/TRAIL-R2 receptor expression. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 307406) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody (Cat. No. 307404) or biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by SAv-PE (Cat. No. 405204)).
- Application References
(PubMed link indicates BioLegend citation) -
- Uno K, et al. 2003. Blood 101:3658.
- Sato K, et al. 2005. J. Immunol. 174:4025.
- Lundgvist A,et al.2006.Cancer Res.14:7317.PubMed
- Product Citations
-
- Braun F, et al. 2015. PLoS One. 10:117994. PubMed
- Grayson KA, et al. 2021. Mol Cancer Ther. 20:833. PubMed
- Jeong D, et al. 2021. eLife. 0.416666666666667. PubMed
- Yerbes R, et al. 2022. Cell Death Dis. 13:906. PubMed
- Ng W, et al. 2021. Pharm Biol. 59:47:00. PubMed
- Vunnam N, et al. 2017. Biophys J. 10.1016/j.bpj.2017.05.038. PubMed
- Wu Y, et al. 2019. Sci Rep. 9:20301. PubMed
- Bernareggi D, et al. 2022. Nat Commun. 13:1899. PubMed
- Grayson KA, et al. 2021. PLoS One. 16:e0246733. PubMed
- Magnussen G, et al. 2012. Biochem Biophys Res Commun. 420:516. PubMed
- Volpin V, et al. 2020. Cancer Immunol Res. 8:1163. PubMed
- Greenlee JD, et al. 2021. eLife. 0.416666666666667. PubMed
- Yao C, et al. 2018. Autophagy. 1.854861111. PubMed
- Ray JE, et al. 2021. Cancer Biol Ther. 22:554. PubMed
- Kolluri KK et al. 2018. eLife. 7 pii: e30224. PubMed
- Brin E, et al. 2018. Oncotarget. 9:36914. PubMed
- Stolfi C, et al. 2011. Mol Cancer Ther. 1.159027778. PubMed
- Ishii Y, et al. 2021. J Biol Chem. 297:101223. PubMed
- Choi Y, et al. 2015. Gut. 64: 1303-1313. PubMed
- Canestraro M, et al. 2010. Cancer Genet Cytogenet. 199:110. PubMed
- RRID
- AB_314677 (BioLegend Cat. No. 307405) AB_2204926 (BioLegend Cat. No. 307406)
- Structure
- TNFR superfamily, 55 kD
- Distribution
-
Broadly expressed on normal and tumor cells
- Function
- Induces apoptosis
- Ligand/Receptor
- TRAIL
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. MacFarlane M, et al. 1997. J. Biol. Chem. 272:25417.
2. Walczak H, et al. 1997. EMBO J. 16:5386.
3. Shigeno M, et al. 2003. Oncogene 22:1653.
4. LaVallee T, et al. 2003. Cancer Res. 63:468.
5. Nimmanapalli R, et al. 2001. Cancer Res. 61:759
- Gene ID
- 8795 View all products for this Gene ID
- UniProt
- View information about CD262 on UniProt.org
