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Purified anti-human CD261 (DR4, TRAIL-R1) Antibody
产品名称:
Purified anti-human CD261 (DR4, TRAIL-R1) Antibody
产品类别:
抗体
产品编号:
307201
产品应用:
307201
[价格]
规格 价格 库存
25µg ¥ 1414 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Cynomolgus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Extracellular domain of DR4-human IgG1 Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: The DJR1 antibody is useful for immunofluorescent staining and flow cytometric analysis of DR4/TRAIL-R1 receptor expression. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 307206) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody or biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by SAv-PE (Cat. No. 405204)).

Application References

(PubMed link indicates BioLegend citation)
  1. Uno K, et al. 2003. Blood 101:3658.
  2. Sato K, et al. 2005. J. Immunol. 174:4025.
  3. Lundqvist A, et al. 2006. Cancer Res. 66:7317. PubMed
  4. Chen KF, et al. 2011. J Pharmacol Exp Ther. 337:155. PubMed
  5. Sonnemann J, et al. 2012. Cancer Biol Ther. 13:417. PubMed
  6. Chandrasekaran S, et al. 2014. PLoS One. 9:111487. PubMed
Product Citations
  1. Winterberg D, et al. 2021. J Clin Med. 10:. PubMed
  2. Sonnemann J, et al. 2012. Cancer Biol Ther. 13:417. PubMed
  3. Chandrasekaran S, et al. 2014. PLoS One. 9:111487. PubMed
  4. Chen K, et al. 2011. J Pharmacol Exp Ther. 337:155. PubMed
  5. Lundqvist A, et al. 2006. Cancer Res. 66:7317. PubMed
RRID
AB_314665 (BioLegend Cat. No. 307201) AB_314666 (BioLegend Cat. No. 307202)

Antigen Details

Structure
TNFR superfamily, 56 kD
Distribution

Activated T cells, tumor cells

Function
Induces apoptosis
Ligand/Receptor
TRAIL
Cell Type
T cells
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Macfarlane M. 2003. Toxicol. Lett. 139:89.
2. Baetu T, et al. 2002. Cytokine Growth Factor Rev. 13:199.
3. Degli-Esposti M. 1999. J. Leukoc. Biol. 65:535.

Gene ID
8797 View all products for this Gene ID
UniProt
View information about CD261 on UniProt.org

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