PE anti-human CD261 (DR4, TRAIL-R1) Antibody
- 产品名称：
- PE anti-human CD261 (DR4, TRAIL-R1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 307205
- 产品应用：
- 307205
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1974 |
1 |
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Cynomolgus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Extracellular domain of DR4-human IgG1 Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: The DJR1 antibody is useful for immunofluorescent staining and flow cytometric analysis of DR4/TRAIL-R1 receptor expression. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 307206) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody or biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by SAv-PE (Cat. No. 405204)).
- Application References
(PubMed link indicates BioLegend citation) -
- Uno K, et al. 2003. Blood 101:3658.
- Sato K, et al. 2005. J. Immunol. 174:4025.
- Lundqvist A, et al. 2006. Cancer Res. 66:7317. PubMed
- Chen KF, et al. 2011. J Pharmacol Exp Ther. 337:155. PubMed
- Sonnemann J, et al. 2012. Cancer Biol Ther. 13:417. PubMed
- Chandrasekaran S, et al. 2014. PLoS One. 9:111487. PubMed
- Product Citations
-
- Braun F, et al. 2015. PLoS One. 10:117994. PubMed
- Grayson KA, et al. 2021. Mol Cancer Ther. 20:833. PubMed
- Liu S, et al. 2021. Mol Ther Oncolytics. 21:303. PubMed
- Ng W, et al. 2021. Pharm Biol. 59:47:00. PubMed
- Grayson KA, et al. 2021. PLoS One. 16:e0246733. PubMed
- Magnussen G, et al. 2012. Biochem Biophys Res Commun. 420:516. PubMed
- Yong A, et al. 2009. Blood. 113:875. PubMed
- Wang Q, et al. 2017. Oncogenesis. 10.1038/oncsis.2017.57. PubMed
- Greenlee JD, et al. 2021. eLife. 0.416666666666667. PubMed
- Yao C, et al. 2018. Autophagy. 1.854861111. PubMed
- Kolluri KK et al. 2018. eLife. 7 pii: e30224. PubMed
- Chen QZ, et al. 2020. Front Immunol. 1.202777778. PubMed
- Ishii Y, et al. 2021. J Biol Chem. 297:101223. PubMed
- Staniek J, et al. 2019. Front Immunol. 10:951. PubMed
- RRID
- AB_314669 (BioLegend Cat. No. 307205) AB_2287472 (BioLegend Cat. No. 307206)
- Structure
- TNFR superfamily, 56 kD
- Distribution
-
Activated T cells, tumor cells
- Function
- Induces apoptosis
- Ligand/Receptor
- TRAIL
- Cell Type
- T cells
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Macfarlane M. 2003. Toxicol. Lett. 139:89.
2. Baetu T, et al. 2002. Cytokine Growth Factor Rev. 13:199.
3. Degli-Esposti M. 1999. J. Leukoc. Biol. 65:535.
- Gene ID
- 8797 View all products for this Gene ID
- UniProt
- View information about CD261 on UniProt.org
