APC anti-human CD261 (DR4, TRAIL-R1) Antibody
- 产品名称：
- APC anti-human CD261 (DR4, TRAIL-R1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 307207
- 产品应用：
- 307207
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 2086 |
1 |
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Cynomolgus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Extracellular domain of DR4-human IgG1 Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: The DJR1 antibody is useful for immunofluorescent staining and flow cytometric analysis of DR4/TRAIL-R1 receptor expression. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 307206) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody or biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by SAv-PE (Cat. No. 405204)).
- Application References
(PubMed link indicates BioLegend citation) -
- Uno K, et al. 2003. Blood 101:3658.
- Sato K, et al. 2005. J. Immunol. 174:4025.
- Lundqvist A, et al. 2006. Cancer Res. 66:7317. PubMed
- Chen KF, et al. 2011. J Pharmacol Exp Ther. 337:155. PubMed
- Sonnemann J, et al. 2012. Cancer Biol Ther. 13:417. PubMed
- Chandrasekaran S, et al. 2014. PLoS One. 9:111487. PubMed
- Product Citations
-
- Cordeau M, et al. 2016. PLoS One. 11:e0164401. PubMed
- Malin D, et al. 2011. Clin Cancer Res. 4.184027778. PubMed
- Liu H, et al. 2020. J Crohns Colitis. 1619:14. PubMed
- Phalke SP, et al. 2019. PLoS One. 14:e0218827. PubMed
- Roybal KT et al. 2016. Cell. 167(2):419-432 . PubMed
- Volpin V, et al. 2020. Cancer Immunol Res. 8:1163. PubMed
- Brin E, et al. 2018. Oncotarget. 9:36914. PubMed
- Choi Y, et al. 2015. Gut. 64: 1303-1313. PubMed
- Zhu ZC, et al. 2019. Cell Death Dis. 10:118. PubMed
- Burger J, et al. 2016. Nat Commun. 7:11589. PubMed
- RRID
- AB_2256112 (BioLegend Cat. No. 307207) AB_2204667 (BioLegend Cat. No. 307208)
- Structure
- TNFR superfamily, 56 kD
- Distribution
-
Activated T cells, tumor cells
- Function
- Induces apoptosis
- Ligand/Receptor
- TRAIL
- Cell Type
- T cells
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Macfarlane M. 2003. Toxicol. Lett. 139:89.
2. Baetu T, et al. 2002. Cytokine Growth Factor Rev. 13:199.
3. Degli-Esposti M. 1999. J. Leukoc. Biol. 65:535.
- Gene ID
- 8797 View all products for this Gene ID
- UniProt
- View information about CD261 on UniProt.org
