Purified anti-Cyclin D1 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 3752	1

Product Details

Verified Reactivity

Human, Mouse, Rat

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Full length recombinant human Cyclin D1

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

WB - Quality tested
IHC-P - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application References (PubMed link indicates BioLegend citation)

Garcia Lozano MC, et al. 2006. An. Otorrinolaringol Ibero Am. 33:257.
Lonardo F, et al. 1999. Cancer Res. 10:2470-6.
Pignataro L, et al. 1998. Anticancer Res. 18:1287.

Product Citations

Kozono S, et al. 2018. Nat Commun. 2.50625. PubMed
Demiroglu-Zergeroglu A, et al. 2020. Cell Biol Int. 44:1934. PubMed

RRID

AB_2566566 (BioLegend Cat. No. 681902)

Antigen Details

Structure: 295 amino acids with a predicted molecular weight of approximately 34 kD.
Distribution: Nucleus and cytosol.
Function: Cyclin D1 plays central roles in cell cycle transition from G1 to S phase.
Interaction: FBXO4, CDK4, CDK6, CCND1/CDK4/CDKN1B, CDKN1B, UHRF2, USP2, INSM1, the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and inhibits CDK4 activity.
Biology Area: Angiogenesis, Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Chromatin Remodeling/Epigenetics, DNA Repair/Replication, Mitochondrial Function, Signal Transduction, Transcription Factors, Ubiquitin/Protein Degradation
Antigen References: 1. Garcia Lozano MC, et al. 2006. An. Otorrinolaringol Ibero Am. 33:257.
2. Lonardo F, et al. 1999. Cancer Res. 59:2470-6.
3. Pignataro L, et al. 1998. Anticancer Res. 18:1287.
4. Darzynkiewicz Z, et al. 2015. Oncotarget. 6:11735.
5. Lamba Saini M, et al. 2015. Diagn. Pathol. 10:32.
6. Casimiro MC, et al. 2014. Expert Opin. Investig. Drugs 23:295.
7. Pestell RG. 2013. Am. J. Pathol. 183:3.
Gene ID: 595 View all products for this Gene ID
UniProt: View information about Cyclin D1 on UniProt.org

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