PE anti-Cyclin D3 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 2226	1

Product Details

Verified Reactivity: Human, Mouse, Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Full length Cyclin D3 of human origin.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: ICFC -?Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
Excitation Laser: Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID: AB_2686979 (BioLegend Cat. No. 684903) AB_2686980 (BioLegend Cat. No. 684904)

Structure: Major isoform has 291 amino acids and predicted molecular weight of 33 kD.
Distribution: Nucleus, cytoplasm and cell membrane.
Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G₁/S transition.
Interaction: CDK14, CDK4, CDK6, ATF5, EIF3K, CDKN1A, ICP0, POLR3GL, and TFIP11.
Biology Area: Cell Biology, Cell Cycle/DNA Replication, Signal Transduction
Antigen References: 1. Liu W,?et al.?2004.?Biochem. Biophys. Res. Commun.?321:954.
2. Sherr CJ. 1993.?Cell?73:1059.
3. Saavedra-?vila NA. 2014.?Proc. Natl. Acad. Sci. USA?111:E3405.
4. Lukas J,?et al.?1996.?Mol. Cell Biol.?16:6917.
5. Wang W,?et al.?2012.?Carcinogenesis.?33:1113.
6. Cato MH,?et al.?2011.?Mol. Cell Biol.?31:127.
7. Zhang Q,?et al.?2014.?Mol. Cell Endocrinol.?382:583.
8. Chi Y,?et al.?2015.?Cancer Cell Int.?15:89.
Gene ID: 896 View all products for this Gene ID
UniProt: View information about Cyclin D3 on UniProt.org