PE anti-mouse LPAM-1 (Integrin α4β7) An-上海雅吉生物科技有限公司

规格	价格	库存
50µg	￥ 1540	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Rat

Immunogen

TK1 cells

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.

Concentration

0.2 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser

Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Application Notes

Additional reported applications (for the relevant formats) include: in vitro and in vivo blocking of cell adhesion^1-4, in vitro induction of TK1 cell aggregation¹, immunoprecipitation⁴, and immunohistochemical staining of frozen sections⁵. It has been reported that the DATK32 mAb is able to block a4?7 mediated lymphocyte adhesion to VCAM-1, MAdCAM-1, and fibronectin in vitro and in vivo.?

Application References (PubMed link indicates BioLegend citation)

Andrew DP, et al. 1994. J. Immunol. 153:3847. (Block)
Berlin C, et al. 1993. Cell 74:185. (Block)
Berlin-Rufenach C, et al. 1999. J. Exp. Med. 189:1467. (Block)
Rivera-Nieves J, et al. 2005. J. Immunol. 174:2343. (Block, IP)
Bogetto L, et al. 2000. Blood 95:2397. (IHC)

Product Citations

Nie J, et al. 2022. Nat Immunol. 23:594. PubMed
Woyciechowski S, Hofmann M, Pircher H 2017. Eur J Immunol. 47:244-250. PubMed
Bennion BG, et al. 2020. Cell Reports. 31(11):107771. PubMed
Duc D et al. 2019. Cell Rep. 29(2):378-390 . PubMed
Ise W, et al. 2018. Immunity. 48:702. PubMed
Bemark M, et al. 2016. Nat Commun. 7: 12698. PubMed
Resch TK, et al. 2018. Sci Rep. 0.722916667. PubMed
Shaikh H, et al. 2021. Front Immunol. 12:689896. PubMed
Nagatake T, et al. 2019. Mucosal Immunol. 12:p1082. PubMed

RRID

AB_493268 (BioLegend Cat. No. 120605) AB_493267 (BioLegend Cat. No. 120606)

Antigen Details

Structure: Integrin family, Ig superfamily, 150 kD/130 kD heterodimer
Distribution: Majority of peripheral lymphocytes, subsets of thymocytes and bone marrow cells
Function: Lymphocyte adhesion
Ligand/Receptor: VCAM-1 (CD106), MAdCAM-1, fibronectin
Cell Type: Lymphocytes, Thymocytes
Biology Area: Cell Biology, Immunology, Neuroscience, Synaptic Biology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Andrew DP, et al. 1994. J. Immunol. 153:3847.
2. Berlin C, et al. 1994. Cell 74:185.
3. Gurish MF, et al. 2001 J. Exp. Med. 194:1243.
4. Hamann A, et al. 1994. J. Immunol. 152:3282.
Gene ID: 311144 View all products for this Gene ID 25713 View all products for this Gene ID
UniProt: View information about LPAM-1 on UniProt.org

上海细胞库

原代细胞

细胞培养

细胞服务

酶联试剂盒

生化试剂盒

PCR试剂盒

抗体蛋白

试剂耗材

首页 > 抗体蛋白 > 抗体

产品详情

Product Details

Antigen Details

联系我们