Purified anti-human CD158b/j (KIR2DL2/L3/S2) Antib-上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 1568	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The DX27 monoclonal antibody reacts with a common epitope of KIR2DL2 (CD158b1, p58.2), KIR2DL3 (CD158b2, p58.3), and KIR2DS2 (CD158j, p50.2). Additional reported applications (for the relevant formats) include: restoring the NK cell cytotoxicity^1,5.

This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of paraffin-embedded tissue sections (IHC-P).

Application References (PubMed link indicates BioLegend citation)

Bakker ABH, et al. 1998. J. Immunol. 160:5239.
Lucas M, et al. 2003. J. Virol. 77:2251.
Goodier M, et al. 2000. J. Immunol. 165:139.
Yawata M, et al. 2002. Immunogenetics 54:543.
Valiante NM, et al. 1997. Immunity 7:739.

Product Citations

Ferrari de Andrade L, et al. 2020. Cancer Immunol Res. 0.867361111. PubMed
Zal B, et al. 2008. J Immunol. 181:5233. PubMed
Niu C, et al. 2018. Front Immunol. 9:1759. PubMed

RRID

AB_314933 (BioLegend Cat. No. 312602)

Antigen Details

Structure: Immunoglobulin superfamily member, contains two immunoglobulin C2-type domains, type I membrane protein
Distribution: NK cells and a subset of T cells
Function: Inhibits cytotoxic function of NK and T cells upon interacting with specific HLA-C antigens on target cell
Ligand/Receptor: HLA-C antigens such as HLA-Cw1, HLA-Cw3, HLA-Cw7
Cell Type: NK cells, T cells
Biology Area: Immunology
Molecular Family: CD Molecules
Antigen References: 1. Colonna M, et al. 1995. Science 268:405.
2. Uhrburg M, et al. 1997. Immunity 7:753.
3. Wagtmann N, et al. 1995. Immunity 3:801.
4. Dohring C, et al. 1996. Immunogenetics 44:227.
5. Maenaka K, et al. 1999. Structure 7:391.
Gene ID: 3803 View all products for this Gene ID
UniProt: View information about CD158b/j on UniProt.org

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