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FITC anti-human CD158b/j (KIR2DL2/L3/S2) Antibody
产品名称：
FITC anti-human CD158b/j (KIR2DL2/L3/S2) Antibody
产品类别：
抗体
产品编号：
312603
产品应用：
312603
[价格]
规格 价格 库存
25tests ￥ 1414 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application Notes

The DX27 monoclonal antibody reacts with a common epitope of KIR2DL2 (CD158b1, p58.2), KIR2DL3 (CD158b2, p58.3), and KIR2DS2 (CD158j, p50.2). Additional reported applications (for the relevant formats) include: restoring the NK cell cytotoxicity1,5.

This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of paraffin-embedded tissue sections (IHC-P).

Application References

(PubMed link indicates BioLegend citation)
  1. Bakker ABH, et al. 1998. J. Immunol. 160:5239.
  2. Lucas M, et al. 2003. J. Virol. 77:2251.
  3. Goodier M, et al. 2000. J. Immunol. 165:139.
  4. Yawata M, et al. 2002. Immunogenetics 54:543.
  5. Valiante NM, et al. 1997. Immunity 7:739.
Product Citations
  1. Busch A, et al. 2008. J Immunol. 181:3965. PubMed
  2. Caduff N, et al. 2021. Cell Reports. 35(5):109056. PubMed
  3. Crellin N, et al. 2010. J Exp Med. 207:281. PubMed
  4. Gruber CN, et al. 2020. Immunity. 53(3):672-684. PubMed
  5. Reches A, et al. 2016. J Immunol. 196: 4967 - 4976. PubMed
  6. Harris LD, et al. 2020. Front Cell Infect Microbiol. 10:120. PubMed
  7. Goodridge J, et al. 2013. J Immunol. 191:3553. PubMed
  8. Kwant-Mitchell A, et al. 2009. PLoS One. 4:e8379. PubMed
  9. Bennstein SB, et al. 2020. eLife. 9:e55232.. PubMed
RRID
AB_314934 (BioLegend Cat. No. 312603) AB_2296486 (BioLegend Cat. No. 312604)

Antigen Details

Structure
Immunoglobulin superfamily member, contains two immunoglobulin C2-type domains, type I membrane protein
Distribution

NK cells and a subset of T cells

Function
Inhibits cytotoxic function of NK and T cells upon interacting with specific HLA-C antigens on target cell
Ligand/Receptor
HLA-C antigens such as HLA-Cw1, HLA-Cw3, HLA-Cw7
Cell Type
NK cells, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Colonna M, et al. 1995. Science 268:405.
2. Uhrburg M, et al. 1997. Immunity 7:753.
3. Wagtmann N, et al. 1995. Immunity 3:801.
4. Dohring C, et al. 1996. Immunogenetics 44:227.
5. Maenaka K, et al. 1999. Structure 7:391.

Gene ID
3803 View all products for this Gene ID
UniProt
View information about CD158b/j on UniProt.org

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