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首页 > 抗体蛋白 > 抗体
FITC anti-mouse CD80 Antibody
产品名称：
FITC anti-mouse CD80 Antibody
产品类别：
抗体
产品编号：
104705
产品应用：
104705
[价格]
规格 价格 库存
50µg ￥ 994 1

产品详情

Product Details

Verified Reactivity
Mouse
Reported Reactivity
Dog
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
CHO cell line transfected with mouse B7 (CD80)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation2, in vitro and in vivo blocking of CTLA-4 Ig to CD80 by blocking costimulation of T cells by activated B cells2-4, and immunohistochemical staining of acetone-fixed frozen sections1,4. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 104747-104752).

Application References

(PubMed link indicates BioLegend citation)
  1. Harlan DM, et al. 1994. P. Natl. Acad. Sci. USA 91:3137. (IHC)
  2. Razi-Wolf Z, et al. 1992. P. Natl. Acad. Sci. USA 89:4210. (Block, IP)
  3. Hathcock KS, et al. 1994. J. Exp. Med. 180:631. (Block)
  4. Herold KC, et al. 1997. J. Immunol. 158:984. (Block, IHC)
  5. Ma XT, et al. 2006. Cancer Res. 66:1169.
  6. Andoniou CE, et al. 2005. Nature Immunology 6:1011. (FC)
  7. Lawson BR, et al. 2007. J. Immunol. 178:5366.
  8. Turnquist HR, et al. 2007. J. Immunol. 178:7018.
  9. Misra RS, et al. 2010. J. Exp Med. 207:1775. PubMed
  10. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
  11. Philipsen L, et al. 2013. Mol Cell Proteomics. 12:2551. PubMed
Product Citations
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  6. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  7. Hreha TN, et al. 2020. Front Immunol. 1.597916667. PubMed
  8. Porciello N, et al. 2018. Nat Commun. 9:1080. PubMed
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  17. Bommireddy R, et al. 2020. Vaccines (Basel). 8:. PubMed
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  19. Kimura A, et al. 2018. J Exp Med. 215:2197. PubMed
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  22. Li X, et al. 2014. PLoS One. 9:108192. PubMed
  23. Pandey V, et al. 2021. eLife. 0.416666666666667. PubMed
  24. Balashov L 2015. Mult Scler. 21: 1131-1138. PubMed
  25. Liang Y, et al. 2014. J Immunol. 192:1277. PubMed
  26. Lv Z, et al. 2020. Oncoimmunology. 9:1747688. PubMed
  27. Funk KE, et al. 2019. J Neuroinflammation. 16:22. PubMed
  28. Snell LM, et al. 2018. Immunity. 49:678. PubMed
  29. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  30. Kornst?dt L, et al. 2021. Front Immunol. 11:607048. PubMed
  31. Qi T, et al. 2020. Cell Rep. 33:108452. PubMed
  32. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  33. Zhou Y, et al. 2020. Front Pharmacol. 10:1579. PubMed
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  35. Cheng Y, et al. 2020. PLoS Pathog. 16:e1008569. PubMed
  36. Li Y, et al. 2021. Sci Transl Med. 13:. PubMed
  37. Ji W, et al. 2018. Evid Based Complement Alternat Med. 2017:3272649. PubMed
  38. Xiong W, et al. 2022. Adv Sci (Weinh). 9:e2103029. PubMed
  39. Benhamron S, et al. 2012. PLoS One. 7:e35602. PubMed
  40. Shiozawa S, et al. 2022. iScience. 25:103537. PubMed
  41. Gómez LA, et al. 2020. Front Microbiol. 11:1586. PubMed
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  43. Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed
  44. Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
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  52. Yin X, et al. 2020. Cell Rep. 33:108278. PubMed
  53. Nicolas-Boluda A, et al. 2021. eLife. 10:00. PubMed
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  55. Wawrzyniak M, et al. 2021. Pharmacol Res Perspect. 9:e00837. PubMed
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  59. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
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RRID
AB_313126 (BioLegend Cat. No. 104705) AB_313127 (BioLegend Cat. No. 104706)

Antigen Details

Structure
Ig superfamily, 60 kD
Distribution

Macrophages, activated B cells and T cells, dendritic cells

Function
T cell costimulation
Ligand/Receptor
CD28 (stimulatory), CD152(CTLA4) (inhibitory)
Cell Type
B cells, Dendritic cells, Macrophages, T cells, Tregs
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Linsley PS, et al. 1991. J. Exp. Med. 174:561.
3. Salomon B, et al. 2001. Annu. Rev. Immunol. 19:225.

Gene ID
12519 View all products for this Gene ID
UniProt
View information about CD80 on UniProt.org

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