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首页 > 抗体蛋白 > 抗体
APC anti-mouse CD80 Antibody
产品名称：
APC anti-mouse CD80 Antibody
产品类别：
抗体
产品编号：
104713
产品应用：
104713
[价格]
规格 价格 库存
25µg ￥ 1232 1

产品详情

Product Details

Verified Reactivity
Mouse
Reported Reactivity
Dog
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
CHO cell line transfected with mouse B7 (CD80)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation2, in vitro and in vivo blocking of CTLA-4 Ig to CD80 by blocking costimulation of T cells by activated B cells2-4, and immunohistochemical staining of acetone-fixed frozen sections1,4. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 104747-104752).

Application References

(PubMed link indicates BioLegend citation)
  1. Harlan DM, et al. 1994. P. Natl. Acad. Sci. USA 91:3137. (IHC)
  2. Razi-Wolf Z, et al. 1992. P. Natl. Acad. Sci. USA 89:4210. (Block, IP)
  3. Hathcock KS, et al. 1994. J. Exp. Med. 180:631. (Block)
  4. Herold KC, et al. 1997. J. Immunol. 158:984. (Block, IHC)
  5. Ma XT, et al. 2006. Cancer Res. 66:1169.
  6. Andoniou CE, et al. 2005. Nature Immunology 6:1011. (FC)
  7. Lawson BR, et al. 2007. J. Immunol. 178:5366.
  8. Turnquist HR, et al. 2007. J. Immunol. 178:7018.
  9. Misra RS, et al. 2010. J. Exp Med. 207:1775. PubMed
  10. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
  11. Philipsen L, et al. 2013. Mol Cell Proteomics. 12:2551. PubMed
Product Citations
  1. Yao RQ, et al. 2022. Theranostics. 12:4606. PubMed
  2. Miao L, et al. 2020. Theranostics. 0.7625. PubMed
  3. Català C, et al. 2022. iScience. 25:105078. PubMed
  4. Hreha TN, et al. 2020. Front Immunol. 1.597916667. PubMed
  5. Clement M, et al. 2016. PLoS Pathog. 12:e1006050. PubMed
  6. Tyagi AM et al. 2018. Immunity. 49(6):1116-1131 . PubMed
  7. Diao L, et al. 2022. iScience. 25:105511. PubMed
  8. Onodera T, et al. 2012. Proc Natl Acad Sci U S A. 109:2485. PubMed
  9. Britton GJ et al. 2019. Immunity. 50(1):212-224 . PubMed
  10. ?krnjug I, et al. 2014. PLoS One. 9:110150. PubMed
  11. Jeljeli M, et al. 2020. Cell Rep. 33:108325. PubMed
  12. Uchil PD et al. 2018. Cell host & microbe. 25(1):87-100 . PubMed
  13. Terashima Y, et al. 2020. Nat Commun. 11:609. PubMed
  14. Wang Z, et al. 2021. J Virol. 95:e0141421. PubMed
  15. Ma J, et al. 2021. Curr Protoc. 1:e144. PubMed
  16. Stewart JM, et al. 2020. ACS Biomater Sci Eng. 6:5941. PubMed
  17. Onodera T, et al. 2016. J Immunol. 196: 4172 - 4184. PubMed
  18. Russler-Germain EV, et al. 2021. Elife. 10:. PubMed
  19. Horiguchi H, et al. 2019. Genes Dev. 33:1641. PubMed
  20. Xue RY, et al. 2019. Front Immunol. 10:1372. PubMed
  21. Carbone C, et al. 2021. J Immunother Cancer. 9:. PubMed
  22. Mao L, et al. 2022. Front Immunol. 13:833418. PubMed
  23. Chou S, et al. 2016. J Control Release. 244:14-23. PubMed
  24. Assi H, et al. 2014. PLoS One. 9:96318. PubMed
  25. Olson WJ, et al. 2019. Cell Rep. 28:2878. PubMed
  26. Han F, et al. 2020. Invest Ophthalmol Vis Sci. 61:24. PubMed
  27. Guan X, et al. 2022. Nat Commun. 13:2834. PubMed
  28. Feng Y, et al. 2022. J Nanobiotechnology. 20:193. PubMed
  29. Gong N, et al. 2020. Nat Nanotechnol. 1.35625. PubMed
  30. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  31. Ghorbani S, et al. 2022. Nat Commun. 13:2445. PubMed
  32. Wang X, et al. 2022. J Biol Chem. 298:101561. PubMed
  33. Yi H, et al. 2021. Front Immunol. 12:719189. PubMed
  34. Zhao Y, et al. 2020. Immunity. 51(6):1059-1073.e9.. PubMed
  35. Hollern DP, et al. 2020. Cell. 179(5):1191-1206.e21.. PubMed
  36. Zhang J, et al. 2022. Biomater Res. 26:44. PubMed
  37. Peng KT, et al. 2019. Int J Nanomedicine. 14:469. PubMed
  38. Molina MS, et al. 2021. Front Immunol. 12:699128. PubMed
  39. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  40. Knox T, et al. 2019. Sci Rep. 9:6136. PubMed
  41. Xu Y, et al. 2021. iScience. 24:103445. PubMed
  42. Lavoie S, et al. 2020. Gastroenterology. 158:1359. PubMed
  43. Mino T, et al. 2019. Nucleic Acids Res. 47:8838. PubMed
  44. Angulo G, et al. 2021. eLife. 10:00. PubMed
  45. Lucas ED, et al. 2020. Cell Reports. 33(2):108258. PubMed
  46. Chng S, et al. 2016. Sci Rep. 6: 23820. PubMed
  47. Guo S, et al. 2021. Chronic Dis Transl Med. 7:254. PubMed
RRID
AB_313134 (BioLegend Cat. No. 104713) AB_313135 (BioLegend Cat. No. 104714)

Antigen Details

Structure
Ig superfamily, 60 kD
Distribution

Macrophages, activated B cells and T cells, dendritic cells

Function
T cell costimulation
Ligand/Receptor
CD28 (stimulatory), CD152(CTLA4) (inhibitory)
Cell Type
B cells, Dendritic cells, Macrophages, T cells, Tregs
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Linsley PS, et al. 1991. J. Exp. Med. 174:561.
3. Salomon B, et al. 2001. Annu. Rev. Immunol. 19:225.

Gene ID
12519 View all products for this Gene ID
UniProt
View information about CD80 on UniProt.org

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