Purified anti-human CD369 (Dectin-1/CLEC7A) Antibo-上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 2884	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Ectodomain with C-term hFc fusion, RIBLS.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
IHC-F - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The epitope of clone 15E2 is LWEDGSTFSSN. Clone 15E2 can recognize the epitope in the presence of Curdlan and Laminarin (CLEC7A ligands). Additional reported applications (for the relevant formats) include: immunohistochemical staining.¹

Application References (PubMed link indicates BioLegend citation)

Ni L, et al. 2010. J. Immunol. 185:3504. (IHC)

Product Citations

Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed
Sander J et al. 2017. Immunity. 47(6):1051-1066 . PubMed

RRID

AB_2561530 (BioLegend Cat. No. 355402)

Antigen Details

Structure: Type II transmemberane C-type lectin, one carbohydrate recognition domain, ITAM containing cytoplasmic tail
Distribution: B cells, low level of some subsets of T cells, monocytes, dendritic cells, macrophages and endothelial cells
Function: Mediates innate immunity to fungal pathogens
Interaction: TLR2, CD37
Ligand/Receptor: Beta-glucan
Cell Type: B cells, Dendritic cells, Endothelial cells, Macrophages, Monocytes, T cells
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family: CD Molecules
Antigen References: 1. Goodridge HS, et al. 2011. Nature 472:471.
2. Saijo S, et al. 2007. Nat. Immunol. 8:39.
3. Brown GD. 2006. Nat. Rev. Immunol. 6:33.
4. Willment JA, et al. 2001. J. Biol. Chem. 276:43818.
5. Yokota K, et al. 2001. Gene 272:51.
Gene ID: 64581 View all products for this Gene ID
UniProt: View information about CD369 on UniProt.org

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