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Purified anti-human LOX-1 Antibody
产品名称:
Purified anti-human LOX-1 Antibody
产品类别:
抗体
产品编号:
358602
产品应用:
358602
[价格]
规格 价格 库存
100µg ¥ 3710 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
LOX-1 ectodomain: Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunofluorescent staining of acetone-fixed frozen human skin sections1.

Application References

(PubMed link indicates BioLegend citation)
  1. Li D, et al. 2012. J. Exp. Med. 209:109. (IHC)
RRID
AB_2562272 (BioLegend Cat. No. 358602)

Antigen Details

Structure
Single pass, type II, transmembrane protein, 31 kD, homodimer, member of the C-type lectin superfamily.
Distribution

Endothelial cells, smooth muscle, platelets, fibroblasts, macrophages; Upregulated by inflammatory and oxidative stimuli

Function
Scavenger receptor, involved in endocytosis, phagocytosis and cytokine production
Ligand/Receptor
Recognizes numerous ligands including lipoproteins, apoptotic cells, heat shock proteins, C-reactive protein, oxidized LDL
Cell Type
Dendritic cells, Endothelial cells, Fibroblasts, Macrophages, Platelets
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules
Antigen References

1. Yin Y, et al. 2013. Eur. J. Cell Biol. 92:150.?
2. Khaidakov M. and Mehta JL. 2012. PLoS One. 7:e46973.?
3. Sawamura T, et al. 2012. Curr. Opin. Lipidol. 23:439.?
4. Lin FY, et al. 2011. J. Immunol. 186:4405.?
5. Parlato S, et al. 2010. Blood 115:1554.

Gene ID
4973 View all products for this Gene ID
UniProt
View information about LOX-1 on UniProt.org

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