Purified anti-human CD70 Antibody
- 产品名称：
- Purified anti-human CD70 Antibody
- 产品编号：
- 355101
- 产品类别：
- 牛ELISA试剂盒
- 检测样本：
- 355101
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- CD70-transfected L cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications for the relevant formats include: blocking of plasmacytoid dendritic cell induced B cell proliferation and Ig secretion1.
- Application References
(PubMed link indicates BioLegend citation) -
- Shaw J, et al. 2010. Blood 115:3051. (Block)
- Product Citations
-
- Gabitova-Cornell L, et al. 2020. Cancer Cell. 38(4):567-583.e11. PubMed
- Tian Y, et al. 2019. Cell Rep. 29:4482. PubMed
- Francescone R, et al. 2020. Cancer Discovery. 11(2):446-479. PubMed
- Abolhassani H, et al. 2017. J Exp Med . 214(1):91-106. PubMed
- Ravell JC, et al. 2020. J Clin Invest. 130:507. PubMed
- Martin E, et al. 2020. JCI Insight. :5. PubMed
- RRID
- AB_2561428 (BioLegend Cat. No. 355101) AB_2561429 (BioLegend Cat. No. 355102)
- Structure
- Type II transmembrane glycoprotein, member of the tumor necrosis factor superfamily, 50 kD
- Distribution
-
Activated T cells and B cells, activated NK cells, activated plasmacytoid dendritic cells, some B cell lymphomas
- Function
- Role in T cell proliferation, generation of cytolytic and memory T cells, B cell proliferation and differentiation
- Ligand/Receptor
- CD27
- Cell Type
- B cells, Dendritic cells, NK cells, T cells
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Bowman MR, et al. 1994. J. Immunol. 152:1756.
2. Shaw J, et al. 2010. Blood 115:3051.
3. Keller AM, et al. 2009. Blood 113:5167.
- Gene ID
- 970 View all products for this Gene ID
- UniProt
- View information about CD70 on UniProt.org
