PE anti-ATM Phospho (Ser1981) Antibody
- 产品名称：
- PE anti-ATM Phospho (Ser1981) Antibody
- 英文名称：
- 型号：
- 651203
- 产品库存：
- 1
- 产品价格：
- 电议
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- KLH conjugated synthetic peptide SLAFEEGSpQSTTISS
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis.?For flow cytometric staining, the suggested use of this reagent is ≤0.125 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Patent No. USA: 7,108,992
- Product Citations
-
- Alissafi T, et al. 2020. Cell Metabolism. 32(4):591-604.e7. PubMed
- Ryl T et al. 2017. Cell systems. 5(3):237-250 . PubMed
- Welch G, et al. 2022. Sci Adv. 8:eabo4662. PubMed
- Yoon Y, et al. 2016. Stem Cell Reports. 7:840-853. PubMed
- Barili V, et al. 2020. Nat Commun. 0.877777778. PubMed
- Lehrke MJ, et al. 2021. Elife. 10:. PubMed
- RRID
- AB_2562654 (BioLegend Cat. No. 651203) AB_2562655 (BioLegend Cat. No. 651204)
- Structure
- 3056 amino acids, 350 kD.
- Distribution
-
Primarily nuclear, also found in endocytic vesicles.
- Function
- Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis, and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor.
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Transcription Factors, Ubiquitin/Protein Degradation
- Molecular Family
- Phospho-Proteins
- Antigen References
-
1. Lee JH and Paull TT 2007. Oncogene 26:7741.
2. Bakkenist CJ and Kastan MB 2003. Nature 421:499.
3. McConville CM, et al. 1996. Am. J. Hum. Genet. 59:320.
4. Tang X, et al. 2008. Mol. Cell Biol. 28:2559.
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- Gene ID
- 472 View all products for this Gene ID
- UniProt
- View information about ATM on UniProt.org
