PE anti-SHIP-1 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 2124	1

Product Details

Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human SHIP fusion protein in CFA/IFA
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: ICFC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes: Specific to human SHIP-1 and cross reactive with mouse SHIP-1.
RRID: AB_2562867 (BioLegend Cat. No. 656603) AB_2562868 (BioLegend Cat. No. 656604)

Structure: 1189 or 1188 amino acids, predicted molecular weight of 150 kD with the characteristic N-terminal SH2 domain, inositol phosphatase domain, and C-terminal protein interaction domains
Distribution: Cytoplasm and membrane; translocates to the plasma membrane when activated
Function: Negative regulator of hematopoietic cell proliferation and survival
Interaction: Phosphatidylinositol-3,4,5-triphosphate
Ligand/Receptor: SHC1, DOK1, DOK3, PTPN11/SHP-2, SLAMF1/CD150, PTPN11 FCGR2A FCGR2B, FCGR3, SRC and TEC et al.
Cell Type: B cells, Dendritic cells, Tregs
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, DNA Repair/Replication, Immunology, Innate Immunity, Signal Transduction
Molecular Family: Protein Kinases/Phosphatase
Antigen References: 1. Condé C, et al. 2011. Biochem. Pharmacol. 82:1320.
2. Parry RV, et al. 2010. Biochim Biophys Acta. 1804:592.
3. Ghansah T, et al. 2012. Oncoimmunology. 1:984.
4. Banh C, et al. 2012. Blood 120:4583.
5. Blunt MD, et al. 2012. Front. Immunol. 3:226.
Gene ID: 3635 View all products for this Gene ID
UniProt: View information about SHIP-1 on UniProt.org