PE anti-mouse CD134 (OX-40) Antibody
- 产品名称：
- PE anti-mouse CD134 (OX-40) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 119409
- 产品应用：
- 119409
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse OX-40-CD4 chimeric protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Clone OX-86 has been reported to act as an agonist and stimulate OX-40.
- Application References
(PubMed link indicates BioLegend citation) -
- Higgins LM, et al. 1999. J. Immunol. 162:486. (FC, IHC)
- Al-Shamkhani A, et al. 1996. Eur. J. Immunol. 26:1695. (Costim)
- del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
- Product Citations
-
- Martin S, et al. 2016. PLoS One. 11: 0155189. PubMed
- Xie A et al. 2017. Endocrinology. 158(10):3140-3151 . PubMed
- Sekiya T et al. 2018. Cell reports. 24(6):1627-1638 . PubMed
- Kawakami R, et al. 2021. Immunity. 54(5):947-961.e8. PubMed
- Sebastian M, et al. 2016. J Immunol. 196: 144 - 155. PubMed
- Triplett T, et al. 2015. Cancer Immunol Res. 3:526. PubMed
- Trefzer A, et al. 2021. Cell Reports. 34(6):108748. PubMed
- Andersen L, et al. 2020. Cell Reports. 29(13):4447-4459.e6.. PubMed
- Halim TYF et al. 2018. Immunity. 48(6):1195-1207 . PubMed
- Alam IS, et al. 2020. Cancer Res. 80:4780. PubMed
- Ersching J, et al. 2016. PLoS Pathog. 12: 1005698. PubMed
- RRID
- AB_2272150 (BioLegend Cat. No. 119409) AB_2207344 (BioLegend Cat. No. 119410)
- Structure
- TNF receptor superfamily, 50 kD
- Distribution
-
Activated CD4+ and CD8+?T cells, activated B cells.
- Function
- Receptor for OX-40 ligand, provides co-stimulatory signal for lymphocyte proliferation independent of CD28; thought to play a role in the pathogenesis of some autoimmune diseases
- Ligand/Receptor
- OX-40 ligand
- Cell Type
- B cells, T cells, Tregs
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
-
1. Al-Shamkhani A,?et al.?1996.?Eur. J. Immunol.?26:1695.
2. Weinberg AD,?et al.?1999.?J. Immunol.?162:1818.
3. Akira H,?et al.?1999.?J. Immunol.?162:7058.
4. Pippig SD,?et al.?1999.?J. Immunol.?163:6520.
5. Higgins LM,?et al.?1999.?J. Immunol.?162:486.
- Gene ID
- 22163 View all products for this Gene ID
- UniProt
- View information about CD134 on UniProt.org
