Purified anti-IL-36α Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 2748	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Full length recombinant human IL-36α (NP_055255) produced in HEK 293T cell line.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2565642 (BioLegend Cat. No. 676402)

Antigen Details

Structure: Full length IL-36α contains 167 amino acids with a predicted molecular weight of 17.7 kD. Proccessing at the N-terminal of IL-36α results in higher potency.
Distribution: Monocytes, T and B cells, spleen, bone marrow, tonsils, lymph nodes, skin, lung, fetal brain, stomach, and adipose tissue.
Function: IL-36α participates in inflammatory reactions, induces multiple cytokines in vivo and in vitro, and is involved in skin homeostasis and reduction of adipocyte differentiation. IL-17 and TNF induce IL-36α expression in keratinocytes, and IL-22 synergizes this induction. EGF also regulates the expression of IL-36α in the skin.
Interaction: Macrophages, adipocytes, lung fibroblasts, bone marrow dendritic cells, and T cells.
Ligand/Receptor: IL36R/IL-RAcP.
Cell Type: B cells, Dendritic cells, Monocytes, T cells
Biology Area: Angiogenesis, Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family: Cytokines/Chemokines
Antigen References: 1. Gresnigt MS and van de Veerdonk FL. 2013. Semin? Immunol. 6:458.
2. Towne JE and Sims JE. 2012. Curr. Opin. Pharmacol. 12:486.
3. Vigne S, et al. 2011. Blood 118:5813.
4. Towne JE, et al. 2011. J. Biol. Chem. 286:42594.
5. Chustz RT, et al. 2011. J. Respir. Cell Mol. Biol. 45:145.
6. Vos JB, et al. 2005. Physiol. Genomics 21:324.
7. Pan QZ, et al. 2013. Cancer Immunol. Immunother. 62:1675.
Gene ID: 27179 View all products for this Gene ID
UniProt: View information about IL-36 on UniProt.org

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